GSTO2

From Wikipedia, the free encyclopedia

Glutathione S-transferase omega 2

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3Q18, 3Q19, 3QAG

Identifiers

GSTO2; GSTO 2-2; bA127L20.1

External IDs

OMIM: 612314 MGI: 1915464 HomoloGene: 57057 ChEMBL: 2161 GeneCards: GSTO2 Gene

1.20.4.2, 1.8.5.1, 2.5.1.18

Gene Ontology
Molecular function	• glutathione transferase activity • oxidoreductase activity • glutathione dehydrogenase (ascorbate) activity • methylarsonate reductase activity
Cellular component	• cytosol
Biological process	• vitamin metabolic process • water-soluble vitamin metabolic process • xenobiotic metabolic process • L-ascorbic acid metabolic process • small molecule metabolic process • oxidation-reduction process • cellular response to arsenic-containing substance
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000065621

ENSMUSG00000025069

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 10:
106.03 – 106.06 Mb

Chr 19:
47.87 – 47.89 Mb

PubMed search

Glutathione S-transferase omega-2 is an enzyme that in humans is encoded by the GSTO2 gene.^[1]^[2]

References

↑ Whitbread AK, Tetlow N, Eyre HJ, Sutherland GR, Board PG (Mar 2003). "Characterization of the human Omega class glutathione transferase genes and associated polymorphisms". Pharmacogenetics 13 (3): 131–44. doi:10.1097/01.fpc.0000054062.98065.6e. PMID 12618591.
↑ "Entrez Gene: GSTO2 glutathione S-transferase omega 2".

Further reading

White DL, Li D, Nurgalieva Z, El-Serag HB (2008). "Genetic variants of glutathione S-transferase as possible risk factors for hepatocellular carcinoma: a HuGE systematic review and meta-analysis". Am. J. Epidemiol. 167 (4): 377–89. doi:10.1093/aje/kwm315. PMID 18065725.
Calarco JA, Xing Y, Cáceres M, et al. (2007). "Global analysis of alternative splicing differences between humans and chimpanzees". Genes Dev. 21 (22): 2963–75. doi:10.1101/gad.1606907. PMC 2049197. PMID 17978102.
Leite JL, Morari EC, Granja F, et al. (2007). "Influence of the glutathione s-transferase gene polymorphisms on the susceptibility to basal cell skin carcinoma". Revista médica de Chile 135 (3): 301–6. PMID 17505575.
Wahner AD, Glatt CE, Bronstein JM, Ritz B (2007). "Glutathione S-transferase mu, omega, pi, and theta class variants and smoking in Parkinson's disease". Neurosci. Lett. 413 (3): 274–8. doi:10.1016/j.neulet.2006.11.053. PMC 1864949. PMID 17194543.
Morari EC, Lima AB, Bufalo NE, et al. (2006). "Role of glutathione-S-transferase and codon 72 of P53 genotypes in epithelial ovarian cancer patients". J. Cancer Res. Clin. Oncol. 132 (8): 521–8. doi:10.1007/s00432-006-0099-3. PMID 16788846.
Pongstaporn W, Rochanawutanon M, Wilailak S, et al. (2006). "Genetic alterations in chromosome 10q24.3 and glutathione S-transferase omega 2 gene polymorphism in ovarian cancer". J. Exp. Clin. Cancer Res. 25 (1): 107–14. PMID 16761626.
Marahatta SB, Punyarit P, Bhudisawasdi V, et al. (2006). "Polymorphism of glutathione S-transferase omega gene and risk of cancer". Cancer Lett. 236 (2): 276–81. doi:10.1016/j.canlet.2005.05.020. PMID 15992993.
Wang L, Xu J, Ji C, et al. (2005). "Cloning, expression and characterization of human glutathione S-transferase Omega 2". Int. J. Mol. Med. 16 (1): 19–27. PMID 15942673.
Ozturk A, Desai PP, Minster RL, et al. (2005). "Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease". Neurobiol. Aging 26 (8): 1161–5. doi:10.1016/j.neurobiolaging.2004.11.001. PMID 15917099.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Whitbread AK, Mellick GD, Silburn PA, et al. (2004). "Glutathione transferase Omega class polymorphisms in Parkinson disease". Neurology 62 (10): 1910–1. PMID 15159516.
Arning L, Jagiello P, Wieczorek S, et al. (2004). "Glutathione S-Transferase Omega 1 variation does not influence age at onset of Huntington's disease". BMC Med. Genet. 5: 7. doi:10.1186/1471-2350-5-7. PMC 394327. PMID 15040808.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article is issued from Wikipedia. The text is available under the Creative Commons Attribution/Share Alike; additional terms may apply for the media files.