GSK3A

From Wikipedia, the free encyclopedia

Glycogen synthase kinase 3 alpha

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2DFM

Identifiers

Symbols

GSK3A; DKFZp686D0638

External IDs

OMIM: 606784 MGI: 2152453 HomoloGene: 88581 ChEMBL: 2850 GeneCards: GSK3A Gene

EC number

2.7.11.1, 2.7.11.26

Gene Ontology
Molecular function	• protein serine/threonine kinase activity • protein binding • ATP binding • protein kinase A catalytic subunit binding • tau-protein kinase activity
Cellular component	• cytosol • beta-catenin destruction complex
Biological process	• regulation of systemic arterial blood pressure • cardiac left ventricle morphogenesis • glycogen metabolic process • protein phosphorylation • activation of signaling protein activity involved in unfolded protein response • epidermal growth factor receptor signaling pathway • nervous system development • insulin receptor signaling pathway • fibroblast growth factor receptor signaling pathway • negative regulation of UDP-glucose catabolic process • Wnt receptor signaling pathway • positive regulation of cAMP biosynthetic process • endoplasmic reticulum unfolded protein response • negative regulation of TOR signaling cascade • cellular response to insulin stimulus • cellular protein metabolic process • innate immune response • negative regulation of glycogen biosynthetic process • positive regulation of protein catabolic process • positive regulation of heart contraction • negative regulation of glucose import • negative regulation of insulin receptor signaling pathway • neurotrophin TRK receptor signaling pathway • phosphatidylinositol-mediated signaling • negative regulation of transferase activity • negative regulation of cell growth involved in cardiac muscle cell development • positive regulation of adrenergic receptor signaling pathway • negative regulation of canonical Wnt receptor signaling pathway • negative regulation of type B pancreatic cell development • negative regulation of glycogen (starch) synthase activity • positive regulation of glycogen (starch) synthase activity
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
42.73 – 42.75 Mb

Chr 7:
25.23 – 25.24 Mb

PubMed search

Glycogen synthase kinase-3 alpha is an enzyme that in humans is encoded by the GSK3A gene.^[1]

Glycogen synthase kinase 3-alpha EC 2.7.1.37 is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase and various transcription factors (e.g., JUN). It also plays a role in the WNT and phosphoinositide 3-kinase (especially PIK3CG) signaling pathways.^[2]^[3]

Model organisms

*Gsk3a* knockout mouse phenotype
Characteristic	Phenotype
Homozygote viability	Normal
Homozygous Fertility	Normal
Body weight	Normal
Anxiety	Normal
Neurological assessment	Normal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Body temperature	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology	Normal
Peripheral blood lymphocytes	Normal
Micronucleus test	Normal
Heart weight	Normal
Skin Histopathology	Normal
All tests and analysis from^[4]^[5]

Model organisms have been used in the study of GSK3A function. A conditional knockout mouse line, called Gsk3a^{tm1a(EUCOMM)Wtsi}^[6]^[7] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.^[8]^[9]^[10]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.^[4]^[11] Twenty one tests were carried out on mutant mice but no significant abnormalities were observed.^[4]

References

↑ Shaw PC, Davies AF, Lau KF, Garcia-Barcelo M, Waye MM, Lovestone S, Miller CC, Anderton BH (Dec 1998). "Isolation and chromosomal mapping of human glycogen synthase kinase-3 alpha and -3 beta encoding genes". Genome 41 (5): 720–7. doi:10.1139/gen-41-5-720. PMID 9809441.
↑ Ali A, Hoeflich KP, Woodgett JR (August 2001). "Glycogen synthase kinase-3: properties, functions, and regulation". Chem. Rev. 101 (8): 2527–40. doi:10.1021/cr000110o. PMID 11749387.
↑ "Entrez Gene: GSK3A glycogen synthase kinase 3 alpha".
↑ 4.0 4.1 4.2 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
↑ "International Knockout Mouse Consortium".
↑ "Mouse Genome Informatics".
↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
↑ Dolgin E (2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
↑ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

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GSK3A

Model organisms

See also

References