GSC (gene)
From Wikipedia, the free encyclopedia
Homeobox protein goosecoid is a protein that in humans is encoded by the GSC gene.[1][2]
This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis.[2]
Koller's sickle is the first to express the chick homeobox gene goosecoid (GSC).[3]
References
- ↑ Blum M, De Robertis EM, Kojis T, Heinzmann C, Klisak I, Geissert D, Sparkes RS (Oct 1994). "Molecular cloning of the human homeobox gene goosecoid (GSC) and mapping of the gene to human chromosome 14q32.1". Genomics 21 (2): 388–393. doi:10.1006/geno.1994.1281. PMID 7916327.
- ↑ 2.0 2.1 "Entrez Gene: GSC goosecoid".
- ↑ Izpisua-Belmonte, Juan Carlos; Eddy M. De Robertis, Kate G. Storey, and Claudio D. Stern (27 August 1993). "The Homeobox Gene goosecoid and the Origin of Organizer Cells in the Early Chick Blastoderm". Cell 74: 645–659. Retrieved 11 November 2013.
Further reading
- Schlade-Bartusiak K, Macintyre G, Zunich J, Cox DW (2008). "A child with deletion (14)(q24.3q32.13) and auditory neuropathy". Am. J. Med. Genet. A 146 (1): 117–123. doi:10.1002/ajmg.a.32064. PMID 18074379.
- Hartwell KA, Muir B, Reinhardt F et al. (2007). "The Spemann organizer gene, Goosecoid, promotes tumor metastasis". Proc. Natl. Acad. Sci. U.S.A. 103 (50): 18969–18974. doi:10.1073/pnas.0608636103. PMC 1748161. PMID 17142318.
- Barrios-Rodiles M, Brown KR, Ozdamar B et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science 307 (5715): 1621–1625. doi:10.1126/science.1105776. PMID 15761153.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Namciu SJ, Friedman RD, Marsden MD et al. (2004). "Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1". Mamm. Genome 15 (3): 162–178. doi:10.1007/s00335-003-2311-y. PMID 15014966.
- Foucher I, Montesinos ML, Volovitch M et al. (2003). "Joint regulation of the MAP1B promoter by HNF3beta/Foxa2 and Engrailed is the result of a highly conserved mechanism for direct interaction of homeoproteins and Fox transcription factors". Development 130 (9): 1867–1876. doi:10.1242/dev.00414. PMID 12642491.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Danilov V, Blum M, Schweickert A et al. (1998). "Negative autoregulation of the organizer-specific homeobox gene goosecoid". J. Biol. Chem. 273 (1): 627–635. doi:10.1074/jbc.273.1.627. PMID 9417125.
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