GPR177
From Wikipedia, the free encyclopedia
| Wntless homolog (Drosophila) | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | WLS; C1orf139; EVI; GPR177; MRP; mig-14 | ||||||||||||
| External IDs | OMIM: 611514 MGI: 1915401 HomoloGene: 11779 GeneCards: WLS Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 79971 | 68151 | |||||||||||
| Ensembl | ENSG00000116729 | ENSMUSG00000028173 | |||||||||||
| UniProt | Q5T9L3 | Q6DID7 | |||||||||||
| RefSeq (mRNA) | NM_001002292 | NM_026582 | |||||||||||
| RefSeq (protein) | NP_001002292 | NP_080858 | |||||||||||
| Location (UCSC) | Chr 1: 68.56 – 68.7 Mb | Chr 3: 159.84 – 159.94 Mb | |||||||||||
| PubMed search | |||||||||||||
G protein-coupled receptor 177 (GPR177), commonly known as Wntless, is a human gene[1] that encodes a receptor for Wnt proteins in Wnt-secreting cells.[2]
Wntless was recently shown to be a cargo for the retromer complex.[2] It has been found essential for hair follicle induction.[3]
References
- ↑ "Entrez Gene: GPR177 G protein-coupled receptor 177".
- ↑ 2.0 2.1 Eaton S (January 2008). "Retromer retrieves wntless". Dev. Cell. 14 (1): 4–6. doi:10.1016/j.devcel.2007.12.014. PMID 18194646.
- ↑ Fu, J.; Hsu, W. (2012). "Epidermal Wnt Controls Hair Follicle Induction by Orchestrating Dynamic Signaling Crosstalk between the Epidermis and Dermis". Journal of Investigative Dermatology. doi:10.1038/jid.2012.407. PMID 23190887.
Further reading
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
- Bänziger C, Soldini D, Schütt C, et al. (2006). "Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells.". Cell 125 (3): 509–22. doi:10.1016/j.cell.2006.02.049. PMID 16678095.
- Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
See also
- GPR177 receptor, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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