GPR17
From Wikipedia, the free encyclopedia
| G protein-coupled receptor 17 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | GPR17; DKFZp686M18273 | ||||||||||||
| External IDs | OMIM: 603071 MGI: 3584514 HomoloGene: 83191 IUPHAR: GPR17 ChEMBL: 1075162 GeneCards: GPR17 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 2840 | 574402 | |||||||||||
| Ensembl | ENSG00000144230 | ENSMUSG00000052229 | |||||||||||
| UniProt | Q13304 | Q6NS65 | |||||||||||
| RefSeq (mRNA) | NM_001161415 | NM_001025381 | |||||||||||
| RefSeq (protein) | NP_001154887 | NP_001020552 | |||||||||||
| Location (UCSC) | Chr 2: 128.4 – 128.41 Mb | Chr 18: 31.94 – 31.95 Mb | |||||||||||
| PubMed search | |||||||||||||
Uracil nucleotide/cysteinyl leukotriene receptor is a protein that in humans is encoded by the GPR17 gene.[1][2] This gene has been found to regulate food intake response mediated by FOXO1.[3]
References
- ↑ Raport CJ, Schweickart VL, Chantry D, Eddy RL Jr, Shows TB, Godiska R, Gray PW (Feb 1996). "New members of the chemokine receptor gene family". J Leukoc Biol 59 (1): 18–23. PMID 8558062.
- ↑ "Entrez Gene: GPR17 G protein-coupled receptor 17".
- ↑ Ren, Hongxia; Orozco, Ian J.; Su, Ya; Suyama, Shigetomo; Gutiérrez-Juárez, Roger; Horvath, Tamas L.; Wardlaw, Sharon L.; Plum, Leona; Arancio, Ottavio; Accili, Domenico. "FoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food Intake". Cell 149 (6): 1314–1326. doi:10.1016/j.cell.2012.04.032.
Further reading
- Macrez-Leprêtre N, Kalkbrenner F, Morel JL et al. (1997). "G protein heterotrimer Galpha13beta1gamma3 couples the angiotensin AT1A receptor to increases in cytoplasmic Ca2+ in rat portal vein myocytes". J. Biol. Chem. 272 (15): 10095–102. doi:10.1074/jbc.272.15.10095. PMID 9092554.
- Bläsius R, Weber RG, Lichter P, Ogilvie A (1998). "A novel orphan G protein-coupled receptor primarily expressed in the brain is localized on human chromosomal band 2q21". J. Neurochem. 70 (4): 1357–65. doi:10.1046/j.1471-4159.1998.70041357.x. PMID 9523551.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Ciana P, Fumagalli M, Trincavelli ML et al. (2006). "The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor". EMBO J. 25 (19): 4615–27. doi:10.1038/sj.emboj.7601341. PMC 1589991. PMID 16990797.
- M. Kandhavelu, M. P. Abbracchio, P. Angeli, M. Buccioni, D. Dal Ben, C. Lammi, D. Lecca, G. Marucci, G. Cristalli. “Site directed mutagenesis of GPR17 receptor” 16th Camerino-Noordwijkerhout Symposium “An Overview on Receptor Chemistry, Camerino, September 9–13,P28, 2007.http://www.unicam.it/farmacia/symposium/abstracts.htm
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