GPM6A

From Wikipedia, the free encyclopedia

Glycoprotein M6A

Identifiers

GPM6A; GPM6; M6A

External IDs

OMIM: 601275 MGI: 107671 HomoloGene: 3864 GeneCards: GPM6A Gene

Gene Ontology
Molecular function	• calcium channel activity
Cellular component	• plasma membrane • cell surface • integral to membrane • filopodium • neuron projection • neuronal cell body • dendritic spine • axonal growth cone
Biological process	• neuron migration • neural retina development • synapse assembly • neuron projection morphogenesis • stem cell differentiation • positive regulation of filopodium assembly
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000150625

ENSMUSG00000031517

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
176.55 – 176.92 Mb

Chr 8:
54.95 – 55.06 Mb

PubMed search

Neuronal membrane glycoprotein M6-a is a protein that in humans is encoded by the GPM6A gene.^[1]^[2]^[3]

References

↑ Olinsky S, Loop BT, DeKosky A, Ripepi B, Weng W, Cummins J, Wenger SL, Yan Y, Lagenaur C, Narayanan V (Sep 1996). "Chromosomal mapping of the human M6 genes". Genomics 33 (3): 532–6. doi:10.1006/geno.1996.0231. PMID 8661015.
↑ Liang YJ, Wu DF, Stumm R, Hollt V, Koch T (Jul 2008). "Membrane glycoprotein M6A promotes mu-opioid receptor endocytosis and facilitates receptor sorting into the recycling pathway". Cell Res 18 (7): 768–79. doi:10.1038/cr.2008.71. PMID 18574501.
↑ "Entrez Gene: GPM6A glycoprotein M6A".

Further reading

Boks MP, Hoogendoorn M, Jungerius BJ et al. (2008). "Do mood symptoms subdivide the schizophrenia phenotype? association of the GMP6A gene with a depression subgroup". American Journal of Medical Genetics 147b (6): 707–11. doi:10.1002/ajmg.b.30667. PMID 18163405.
DeGiorgis JA, Jaffe H, Moreira JE et al. (2005). "Phosphoproteomic analysis of synaptosomes from human cerebral cortex". J. Proteome Res. 4 (2): 306–15. doi:10.1021/pr0498436. PMID 15822905.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Shin BK, Wang H, Yim AM et al. (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". J. Biol. Chem. 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mukobata S, Hibino T, Sugiyama A et al. (2002). "M6a acts as a nerve growth factor-gated Ca(2+) channel in neuronal differentiation". Biochem. Biophys. Res. Commun. 297 (4): 722–8. doi:10.1016/S0006-291X(02)02284-2. PMID 12359212.
Shimizu F, Watanabe TK, Fujiwara T et al. (1996). "Isolation and mapping of the human glycoprotein M6 gene (GPM6A) to 4q33→q34". Cytogenet. Cell Genet. 74 (1–2): 138–9. doi:10.1159/000134401. PMID 8893821.
Yan Y, Narayanan V, Lagenaur C (1996). "Expression of members of the proteolipid protein gene family in the developing murine central nervous system". J. Comp. Neurol. 370 (4): 465–78. doi:10.1002/(SICI)1096-9861(19960708)370:4<465::AID-CNE4>3.0.CO;2-2. PMID 8807448.

Protein: nerve tissue protein

Other

M: CNS

anat (n/s/m/p/4/e/b/d/c/a/f/l/g)/phys/devp

noco (m/d/e/h/v/s)/cong/tumr, sysi/epon, injr

proc, drug (N1A/2AB/C/3/4/7A/B/C/D)

M: PNS

anat (h/r/t/c/b/l/s/a)/phys (r)/devp/prot/nttr/nttm/ntrp

noco/auto/cong/tumr, sysi/epon, injr

proc, drug (N1B)

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