GOSR2
From Wikipedia, the free encyclopedia
| Golgi SNAP receptor complex member 2 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | GOSR2; Bos1; EPM6; GS27 | ||||||||||||
| External IDs | OMIM: 604027 MGI: 1927204 HomoloGene: 37907 GeneCards: GOSR2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9570 | 56494 | |||||||||||
| Ensembl | ENSG00000108433 | ENSMUSG00000020946 | |||||||||||
| UniProt | O14653 | O35166 | |||||||||||
| RefSeq (mRNA) | NM_001012511 | NM_019650 | |||||||||||
| RefSeq (protein) | NP_001012529 | NP_062624 | |||||||||||
| Location (UCSC) | Chr 17: 45 – 45.11 Mb | Chr 11: 103.68 – 103.7 Mb | |||||||||||
| PubMed search | |||||||||||||
Golgi SNAP receptor complex member 2 is a protein that in humans is encoded by the GOSR2 gene.[1][2][3]
This gene encodes a trafficking membrane protein which transports proteins among the medial- and trans-Golgi compartments. Due to its chromosomal location and trafficking function, this gene may be involved in familial essential hypertension. Three transcript variants encoding three different isoforms have been found for this gene.[3]
Interactions
GOSR2 has been shown to interact with USO1[4][5] and STX5.[4][6][7]
References
- ↑ Lowe SL, Peter F, Subramaniam VN, Wong SH, Hong W (November 1997). "A SNARE involved in protein transport through the Golgi apparatus". Nature 389 (6653): 881–4. doi:10.1038/39923. PMID 9349823.
- ↑ Bui TD, Levy ER, Subramaniam VN, Lowe SL, Hong W (May 1999). "cDNA characterization and chromosomal mapping of human golgi SNARE GS27 and GS28 to chromosome 17". Genomics 57 (2): 285–8. doi:10.1006/geno.1998.5649. PMID 10198168.
- ↑ 3.0 3.1 "Entrez Gene: GOSR2 golgi SNAP receptor complex member 2".
- ↑ 4.0 4.1 Shorter, James; Beard Matthew B, Seemann Joachim, Dirac-Svejstrup A Barbara, Warren Graham (April 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". J. Cell Biol. (United States) 157 (1): 45–62. doi:10.1083/jcb.200112127. ISSN 0021-9525. PMC 2173270. PMID 11927603.
- ↑ Allan, B B; Moyer B D, Balch W E (July 2000). "Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion". Science (UNITED STATES) 289 (5478): 444–8. doi:10.1126/science.289.5478.444. ISSN 0036-8075. PMID 10903204.
- ↑ Hay, J C; Chao D S, Kuo C S, Scheller R H (April 1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell (UNITED STATES) 89 (1): 149–58. doi:10.1016/S0092-8674(00)80191-9. ISSN 0092-8674. PMID 9094723.
- ↑ Hay, J C; Klumperman J, Oorschot V, Steegmaier M, Kuo C S, Scheller R H (June 1998). "Localization, Dynamics, and Protein Interactions Reveal Distinct Roles for ER and Golgi SNAREs". J. Cell Biol. (UNITED STATES) 141 (7): 1489–502. doi:10.1083/jcb.141.7.1489. ISSN 0021-9525. PMC 2133002. PMID 9647643.
Further reading
- Hay JC, Chao DS, Kuo CS, Scheller RH (1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell 89 (1): 149–58. doi:10.1016/S0092-8674(00)80191-9. PMID 9094723.
- Hay JC, Klumperman J, Oorschot V et al. (1998). "Localization, Dynamics, and Protein Interactions Reveal Distinct Roles for ER and Golgi SNAREs". J. Cell Biol. 141 (7): 1489–502. doi:10.1083/jcb.141.7.1489. PMC 2133002. PMID 9647643.
- Xu D, Joglekar AP, Williams AL, Hay JC (2001). "Subunit structure of a mammalian ER/Golgi SNARE complex". J. Biol. Chem. 275 (50): 39631–9. doi:10.1074/jbc.M007684200. PMID 11035026.
- Shorter J, Beard MB, Seemann J et al. (2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". J. Cell Biol. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC 2173270. PMID 11927603.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Honda A, Al-Awar OS, Hay JC, Donaldson JG (2005). "Targeting of Arf-1 to the early Golgi by membrin, an ER-Golgi SNARE". J. Cell Biol. 168 (7): 1039–51. doi:10.1083/jcb.200409138. PMC 2171843. PMID 15781476.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Oh JH, Yang JO, Hahn Y et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
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