GOSR1
From Wikipedia, the free encyclopedia
| Golgi SNAP receptor complex member 1 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | GOSR1; GOLIM2; GOS-28; GOS28; GOS28/P28; GS28; P28 | ||||||||||||
| External IDs | OMIM: 604026 MGI: 1858260 HomoloGene: 37977 GeneCards: GOSR1 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9527 | 53334 | |||||||||||
| Ensembl | ENSG00000108587 | ENSMUSG00000010392 | |||||||||||
| UniProt | O95249 | O88630 | |||||||||||
| RefSeq (mRNA) | NM_001007024 | NM_016810 | |||||||||||
| RefSeq (protein) | NP_001007025 | NP_058090 | |||||||||||
| Location (UCSC) | Chr 17: 28.8 – 28.85 Mb | Chr 11: 76.73 – 76.76 Mb | |||||||||||
| PubMed search | |||||||||||||
Golgi SNAP receptor complex member 1 is a protein that in humans is encoded by the GOSR1 gene.[1][2][3][4]
This gene encodes a trafficking membrane protein which transports proteins among the endoplasmic reticulum and the Golgi apparatus and between Golgi compartments. This protein is considered an essential component of the Golgi SNAP receptor (SNARE) complex. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[4]
Interactions
GOSR1 has been shown to interact with USO1,[5] BET1L[5][6] and STX5.[5][7][8][9]
References
- ↑ Subramaniam VN, Peter F, Philp R, Wong SH, Hong W (Jul 1996). "GS28, a 28-kilodalton Golgi SNARE that participates in ER-Golgi transport". Science 272 (5265): 1161–3. doi:10.1126/science.272.5265.1161. PMID 8638159.
- ↑ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Aug 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc Natl Acad Sci U S A 95 (14): 8175–80. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
- ↑ Oka T, Ungar D, Hughson FM, Krieger M (Apr 2004). "The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins". Mol Biol Cell 15 (5): 2423–35. doi:10.1091/mbc.E03-09-0699. PMC 404034. PMID 15004235.
- ↑ 4.0 4.1 "Entrez Gene: GOSR1 golgi SNAP receptor complex member 1".
- ↑ 5.0 5.1 5.2 Shorter, James; Beard Matthew B, Seemann Joachim, Dirac-Svejstrup A Barbara, Warren Graham (Apr 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". J. Cell Biol. (United States) 157 (1): 45–62. doi:10.1083/jcb.200112127. ISSN 0021-9525. PMC 2173270. PMID 11927603.
- ↑ Xu, Yue; Martin Sally, James David E, Hong Wanjin (Oct 2002). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus". Mol. Biol. Cell (United States) 13 (10): 3493–507. doi:10.1091/mbc.E02-01-0004. ISSN 1059-1524. PMC 129961. PMID 12388752.
- ↑ Hay, J C; Chao D S, Kuo C S, Scheller R H (Apr 1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell (UNITED STATES) 89 (1): 149–58. doi:10.1016/S0092-8674(00)80191-9. ISSN 0092-8674. PMID 9094723.
- ↑ Hay, J C; Klumperman J, Oorschot V, Steegmaier M, Kuo C S, Scheller R H (Jun 1998). "Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs". J. Cell Biol. (UNITED STATES) 141 (7): 1489–502. doi:10.1083/jcb.141.7.1489. ISSN 0021-9525. PMC 2133002. PMID 9647643.
- ↑ Subramaniam, V N; Loh E, Hong W (Oct 1997). "N-Ethylmaleimide-sensitive factor (NSF) and alpha-soluble NSF attachment proteins (SNAP) mediate dissociation of GS28-syntaxin 5 Golgi SNAP receptors (SNARE) complex". J. Biol. Chem. (UNITED STATES) 272 (41): 25441–4. doi:10.1074/jbc.272.41.25441. ISSN 0021-9258. PMID 9325254.
Further reading
- Nagahama M, Orci L, Ravazzola M, et al. (1996). "A v-SNARE implicated in intra-Golgi transport". J. Cell Biol. 133 (3): 507–16. doi:10.1083/jcb.133.3.507. PMC 2120813. PMID 8636227.
- Hay JC, Chao DS, Kuo CS, Scheller RH (1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell 89 (1): 149–58. doi:10.1016/S0092-8674(00)80191-9. PMID 9094723.
- Subramaniam VN, Loh E, Hong W (1997). "N-Ethylmaleimide-sensitive factor (NSF) and alpha-soluble NSF attachment proteins (SNAP) mediate dissociation of GS28-syntaxin 5 Golgi SNAP receptors (SNARE) complex". J. Biol. Chem. 272 (41): 25441–4. doi:10.1074/jbc.272.41.25441. PMID 9325254.
- Hay JC, Klumperman J, Oorschot V, et al. (1998). "Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs". J. Cell Biol. 141 (7): 1489–502. doi:10.1083/jcb.141.7.1489. PMC 2133002. PMID 9647643.
- Bui TD, Levy ER, Subramaniam VN, et al. (1999). "cDNA characterization and chromosomal mapping of human golgi SNARE GS27 and GS28 to chromosome 17". Genomics 57 (2): 285–8. doi:10.1006/geno.1998.5649. PMID 10198168.
- Sagiv Y, Legesse-Miller A, Porat A, Elazar Z (2000). "GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28". EMBO J. 19 (7): 1494–504. doi:10.1093/emboj/19.7.1494. PMC 310219. PMID 10747018.
- Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
- Shorter J, Beard MB, Seemann J, et al. (2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". J. Cell Biol. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC 2173270. PMID 11927603.
- Pflanz S, Timans JC, Cheung J, et al. (2002). "IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells". Immunity 16 (6): 779–90. doi:10.1016/S1074-7613(02)00324-2. PMID 12121660.
- Xu Y, Martin S, James DE, Hong W (2003). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus". Mol. Biol. Cell 13 (10): 3493–507. doi:10.1091/mbc.E02-01-0004. PMC 129961. PMID 12388752.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Tai G, Lu L, Wang TL, et al. (2005). "Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network". Mol. Biol. Cell 15 (9): 4011–22. doi:10.1091/mbc.E03-12-0876. PMC 515336. PMID 15215310.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Arasaki K, Taniguchi M, Tani K, Tagaya M (2006). "RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex". Mol. Biol. Cell 17 (6): 2780–8. doi:10.1091/mbc.E05-10-0973. PMC 1474792. PMID 16571679.
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