GNB2L1

From Wikipedia, the free encyclopedia
Guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsGNB2L1; Gnb2-rs1; H12.3; HLC-7; PIG21; RACK1
External IDsOMIM: 176981 MGI: 101849 HomoloGene: 4446 GeneCards: GNB2L1 Gene
Orthologs
SpeciesHumanMouse
Entrez1039914694
EnsemblENSG00000204628ENSMUSG00000020372
UniProtP63244P68040
RefSeq (mRNA)NM_006098NM_008143
RefSeq (protein)NP_006089NP_032169
Location (UCSC)Chr 5:
180.66 – 180.68 Mb		Chr 11:
48.8 – 48.81 Mb
PubMed search
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Guanine nucleotide-binding protein subunit beta-2-like 1, also known as Receptor for activated C kinase 1 (RACK1) is a 32 kDa protein that in humans is encoded by the GNB2L1 gene.[1][2]

Interactions

GNB2L1 has been shown to interact with:

See also

References

  1. ↑ Ron D, Chen CH, Caldwell J, Jamieson L, Orr E, Mochly-Rosen D (March 1994). "Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins". Proc Natl Acad Sci U S A 91 (3): 839–43. doi:10.1073/pnas.91.3.839. PMC 521407. PMID 8302854. 
  2. ↑ Guillemot F, Billault A, Auffray C (July 1989). "Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex". Proc Natl Acad Sci U S A 86 (12): 4594–8. doi:10.1073/pnas.86.12.4594. PMC 287317. PMID 2499885. 
  3. ↑ Yarwood, S J; Steele M R, Scotland G, Houslay M D, Bolger G B (May 1999). "The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform". J. Biol. Chem. (UNITED STATES) 274 (21): 14909–17. doi:10.1074/jbc.274.21.14909. ISSN 0021-9258. PMID 10329691. 
  4. ↑ Steele, M R; McCahill A, Thompson D S, MacKenzie C, Isaacs N W, Houslay M D, Bolger G B (July 2001). "Identification of a surface on the beta-propeller protein RACK1 that interacts with the cAMP-specific phosphodiesterase PDE4D5". Cell. Signal. (England) 13 (7): 507–13. doi:10.1016/S0898-6568(01)00167-X. ISSN 0898-6568. PMID 11516626. 
  5. ↑ 5.0 5.1 5.2 Usacheva, Anna; Tian Xinyong, Sandoval Raudel, Salvi Debra, Levy David, Colamonici Oscar R (September 2003). "The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex". J. Immunol. (United States) 171 (6): 2989–94. ISSN 0022-1767. PMID 12960323. 
  6. ↑ 6.0 6.1 Usacheva, A; Smith R, Minshall R, Baida G, Seng S, Croze E, Colamonici O (June 2001). "The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor". J. Biol. Chem. (United States) 276 (25): 22948–53. doi:10.1074/jbc.M100087200. ISSN 0021-9258. PMID 11301323. 
  7. ↑ Chang, B Y; Conroy K B, Machleder E M, Cartwright C A (June 1998). "RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells". Mol. Cell. Biol. (UNITED STATES) 18 (6): 3245–56. ISSN 0270-7306. PMC 108906. PMID 9584165. 
  8. ↑ Rigas, Anastasia C; Ozanne Daniel M, Neal David E, Robson Craig N (November 2003). "The scaffolding protein RACK1 interacts with androgen receptor and promotes cross-talk through a protein kinase C signaling pathway". J. Biol. Chem. (United States) 278 (46): 46087–93. doi:10.1074/jbc.M306219200. ISSN 0021-9258. PMID 12958311. 
  9. ↑ Wang, Wei; Huang Yan, Zhou Zongxiang, Tang Rong, Zhao Wei, Zeng Li, Xu Ming, Cheng Chao, Gu Shaohua, Ying Kang, Xie Yi, Mao Yumin (January 2002). "Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap)". Int. J. Biochem. Cell Biol. (England) 34 (1): 93–102. doi:10.1016/S1357-2725(01)00094-2. ISSN 1357-2725. PMID 11733189. 
  10. ↑ Yaka, Rami; He Dao-Yao, Phamluong Khanhky, Ron Dorit (March 2003). "Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1". J. Biol. Chem. (United States) 278 (11): 9630–8. doi:10.1074/jbc.M209141200. ISSN 0021-9258. PMID 12524444. 
  11. ↑ Yaka, Rami; Thornton Claire, Vagts Alicia J, Phamluong Khanhky, Bonci Antonello, Ron Dorit (April 2002). "NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (8): 5710–5. doi:10.1073/pnas.062046299. ISSN 0027-8424. PMC 122836. PMID 11943848. 
  12. ↑ Diederichs, Sven; Bäumer Nicole, Ji Ping, Metzelder Stephan K, Idos Gregory E, Cauvet Thomas, Wang Wenbing, Möller Maria, Pierschalski Sarah, Gromoll Jörg, Schrader Mark G, Koeffler H Phillip, Berdel Wolfgang E, Serve Hubert, Müller-Tidow Carsten (August 2004). "Identification of interaction partners and substrates of the cyclin A1-CDK2 complex". J. Biol. Chem. (United States) 279 (32): 33727–41. doi:10.1074/jbc.M401708200. ISSN 0021-9258. PMID 15159402. 
  13. ↑ Croze, E; Usacheva A, Asarnow D, Minshall R D, Perez H D, Colamonici O (November 2000). "Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor". J. Immunol. (UNITED STATES) 165 (9): 5127–32. ISSN 0022-1767. PMID 11046044. 
  14. ↑ Liedtke, Carole M; Yun C H Chris, Kyle Nicole, Wang Dandan (June 2002). "Protein kinase C epsilon-dependent regulation of cystic fibrosis transmembrane regulator involves binding to a receptor for activated C kinase (RACK1) and RACK1 binding to Na+/H+ exchange regulatory factor". J. Biol. Chem. (United States) 277 (25): 22925–33. doi:10.1074/jbc.M201917200. ISSN 0021-9258. PMID 11956211. 
  15. ↑ Ozaki, Toshinori; Watanabe Ken-ichi, Nakagawa Takahito, Miyazaki Kou, Takahashi Masato, Nakagawara Akira (May 2003). "Function of p73, not of p53, is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB". Oncogene (England) 22 (21): 3231–42. doi:10.1038/sj.onc.1206382. ISSN 0950-9232. PMID 12761493. 
  16. ↑ Koehler, J A; Moran M F (May 2001). "RACK1, a protein kinase C scaffolding protein, interacts with the PH domain of p120GAP". Biochem. Biophys. Res. Commun. (United States) 283 (4): 888–95. doi:10.1006/bbrc.2001.4889. ISSN 0006-291X. PMID 11350068. 
  17. ↑ Ron, D; Jiang Z, Yao L, Vagts A, Diamond I, Gordon A (September 1999). "Coordinated movement of RACK1 with activated betaIIPKC". J. Biol. Chem. (UNITED STATES) 274 (38): 27039–46. doi:10.1074/jbc.274.38.27039. ISSN 0021-9258. PMID 10480917. 
  18. ↑ Battle, Michele A; Maher Veronica M, McCormick J Justin (June 2003). "ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways". Biochemistry (United States) 42 (24): 7270–82. doi:10.1021/bi034081y. ISSN 0006-2960. PMID 12809483. 
  19. ↑ Hellberg, Carina B; Burden-Gulley Susan M, Pietz Gregory E, Brady-Kalnay Susann M (March 2002). "Expression of the receptor protein-tyrosine phosphatase, PTPmu, restores E-cadherin-dependent adhesion in human prostate carcinoma cells". J. Biol. Chem. (United States) 277 (13): 11165–73. doi:10.1074/jbc.M112157200. ISSN 0021-9258. PMID 11801604. 
  20. ↑ Mourton, T; Hellberg C B, Burden-Gulley S M, Hinman J, Rhee A, Brady-Kalnay S M (May 2001). "The PTPmu protein-tyrosine phosphatase binds and recruits the scaffolding protein RACK1 to cell-cell contacts". J. Biol. Chem. (United States) 276 (18): 14896–901. doi:10.1074/jbc.M010823200. ISSN 0021-9258. PMID 11278757. 
  21. ↑ Ceci, Marcello; Gaviraghi Cristina, Gorrini Chiara, Sala Leonardo A, Offenhäuser Nina, Marchisio Pier Carlo, Biffo Stefano (December 2003). "Release of eIF6 (p27BBP) from the 1960s subunit allows 1980s ribosome assembly". Nature (England) 426 (6966): 579–84. doi:10.1038/nature02160. PMID 14654845. 
  22. ↑ Edelmann, Mariola J; Iphöfer Alexander, Akutsu Masato, Altun Mikael, di Gleria Katalin, Kramer Holger B, Fiebiger Edda, Dhe-Paganon Sirano, Kessler Benedikt M (March 2009). "Structural basis and specificity of human otubain 1-mediated deubiquitination". Biochem. J. (England) 418 (2): 379–90. doi:10.1042/BJ20081318. PMID 18954305. 
  23. ↑ 23.0 23.1 Liliental, J; Chang D D (January 1998). "Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit". J. Biol. Chem. (UNITED STATES) 273 (4): 2379–83. doi:10.1074/jbc.273.4.2379. ISSN 0021-9258. PMID 9442085. 
  24. ↑ Lee, H-S; Millward-Sadler S J, Wright M O, Nuki G, Al-Jamal R, Salter D M (November 2002). "Activation of Integrin-RACK1/PKCalpha signalling in human articular chondrocyte mechanotransduction". Osteoarthr. Cartil. (England) 10 (11): 890–7. doi:10.1053/joca.2002.0842. ISSN 1063-4584. PMID 12435334. 

Further reading

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