GFI1
From Wikipedia, the free encyclopedia
Zinc finger protein Gfi-1 is a protein that in humans is encoded by the GFI1 gene.[1][2]
Interactions
GFI1 has been shown to interact with PIAS3[3] and RUNX1T1.[4]
References
- ↑ Bell DW, Taguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Gilks CB, Zweidler-McKay P, Grimes HL, Tsichlis PN, Testa JR (July 1995). "Chromosomal localization of a gene, GF1, encoding a novel zinc finger protein reveals a new syntenic region between man and rodents". Cytogenet Cell Genet 70 (3–4): 263–7. doi:10.1159/000134048. PMID 7789186.
- ↑ "Entrez Gene: GFI1 growth factor independent 1".
- ↑ Rödel, B; Tavassoli K, Karsunky H, Schmidt T, Bachmann M, Schaper F, Heinrich P, Shuai K, Elsässer H P, Möröy T (November 2000). "The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3". EMBO J. (ENGLAND) 19 (21): 5845–55. doi:10.1093/emboj/19.21.5845. ISSN 0261-4189. PMC 305799. PMID 11060035.
- ↑ McGhee, Laura; Bryan Josh, Elliott Liza, Grimes H Leighton, Kazanjian Avedis, Davis J Nathan, Meyers Shari (August 2003). "Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism". J. Cell. Biochem. (United States) 89 (5): 1005–18. doi:10.1002/jcb.10548. ISSN 0730-2312. PMID 12874834.
Further reading
- Gilks CB, Bear SE, Grimes HL, Tsichlis PN (1993). "Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein". Mol. Cell. Biol. 13 (3): 1759–68. PMC 359488. PMID 8441411.
- Zweidler-Mckay PA, Grimes HL, Flubacher MM, Tsichlis PN (1996). "Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor". Mol. Cell. Biol. 16 (8): 4024–34. PMC 231398. PMID 8754800.
- Roberts T, Cowell JK (1997). "Cloning of the human Gfi-1 gene and its mapping to chromosome region 1p22". Oncogene 14 (8): 1003–5. doi:10.1038/sj.onc.1200910. PMID 9051000.
- Rödel B, Tavassoli K, Karsunky H, et al. (2000). "The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3". EMBO J. 19 (21): 5845–55. doi:10.1093/emboj/19.21.5845. PMC 305799. PMID 11060035.
- Osawa M, Yamaguchi T, Nakamura Y, et al. (2002). "Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis". Blood 100 (8): 2769–77. doi:10.1182/blood-2002-01-0182. PMID 12351384.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Person RE, Li FQ, Duan Z, et al. (2003). "Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2". Nat. Genet. 34 (3): 308–12. doi:10.1038/ng1170. PMC 2832179. PMID 12778173.
- McGhee L, Bryan J, Elliott L, et al. (2003). "Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism". J. Cell. Biochem. 89 (5): 1005–18. doi:10.1002/jcb.10548. PMID 12874834.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Doan LL, Porter SD, Duan Z, et al. (2004). "Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells". Nucleic Acids Res. 32 (8): 2508–19. doi:10.1093/nar/gkh570. PMC 419458. PMID 15131254.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Dwivedi PP, Anderson PH, Omdahl JL, et al. (2005). "Identification of growth factor independent-1 (GFI1) as a repressor of 25-hydroxyvitamin D 1-alpha hydroxylase (CYP27B1) gene expression in human prostate cancer cells". Endocr. Relat. Cancer 12 (2): 351–65. doi:10.1677/erc.1.00920. PMID 15947108.
- Duan Z, Zarebski A, Montoya-Durango D, et al. (2005). "Gfi1 Coordinates Epigenetic Repression of p21Cip/WAF1 by Recruitment of Histone Lysine Methyltransferase G9a and Histone Deacetylase 1". Mol. Cell. Biol. 25 (23): 10338–51. doi:10.1128/MCB.25.23.10338-10351.2005. PMC 1291230. PMID 16287849.
- Marteijn JA, van der Meer LT, Van Emst L, et al. (2007). "Diminished proteasomal degradation results in accumulation of Gfi1 protein in monocytes". Blood 109 (1): 100–8. doi:10.1182/blood-2006-02-003590. PMID 16888099.
- Dwivedi PP, Anderson PH, Tilley WD, et al. (2007). "Role of oncoprotein growth factor independent-1 (GFI1) in repression of 25-hydroxyvitamin D 1alpha-hydroxylase (CYP27B1): a comparative analysis in human prostate cancer and kidney cells". J. Steroid Biochem. Mol. Biol. 103 (3–5): 742–6. doi:10.1016/j.jsbmb.2006.12.014. PMID 17207994.
- Nakazawa Y, Suzuki M, Manabe N, et al. (2007). "Cooperative interaction between ETS1 and GFI1 transcription factors in the repression of Bax gene expression". Oncogene 26 (24): 3541–50. doi:10.1038/sj.onc.1210140. PMID 17213822.
- Khanna-Gupta A, Sun H, Zibello T, et al. (2007). "Growth factor independence-1 (Gfi-1) plays a role in mediating specific granule deficiency (SGD) in a patient lacking a gene-inactivating mutation in the C/EBPϵ gene". Blood 109 (10): 4181–90. doi:10.1182/blood-2005-05-022004. PMC 1885490. PMID 17244686.
- Marteijn JA, van der Meer LT, van Emst L, et al. (2007). "Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1". Blood 110 (9): 3128–35. doi:10.1182/blood-2006-11-058602. PMID 17646546.
External links
- GFI1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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