GDF15
From Wikipedia, the free encyclopedia
| Growth differentiation factor 15 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | GDF15; GDF-15; MIC-1; MIC1; NAG-1; PDF; PLAB; PTGFB | ||||||||||||
| External IDs | OMIM: 605312 MGI: 1346047 HomoloGene: 3576 GeneCards: GDF15 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9518 | 23886 | |||||||||||
| Ensembl | ENSG00000130513 | ENSMUSG00000038508 | |||||||||||
| UniProt | Q99988 | Q9Z0J7 | |||||||||||
| RefSeq (mRNA) | NM_004864 | NM_011819 | |||||||||||
| RefSeq (protein) | NP_004855 | NP_035949 | |||||||||||
| Location (UCSC) | Chr 19: 18.49 – 18.5 Mb | Chr 8: 70.63 – 70.63 Mb | |||||||||||
| PubMed search | |||||||||||||
Growth differentiation factor 15 (GDF15) is a protein belonging to the transforming growth factor beta superfamily that has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes.[1] GDF15 is also known as TGF-PL, MIC-1, PDF, PLAB, and PTGFB.[2] GDF15 mRNA is most abundant in the liver, with lower levels seen in some other tissues. Its expression in liver can be significantly up-regulated in during injury of organs such as liver, kidney, heart and lung.[1][2][3]
References
- ↑ 1.0 1.1 Zimmers T, Jin X, Hsiao E, McGrath S, Esquela A, Koniaris L (2005). "Growth differentiation factor-15/macrophage inhibitory cytokine-1 induction after kidney and lung injury". Shock 23 (6): 543–8. PMID 15897808.
- ↑ 2.0 2.1 Hsiao E, Koniaris L, Zimmers-Koniaris T, Sebald S, Huynh T, Lee S (2000). "Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury". Mol Cell Biol 20 (10): 3742–3751. doi:10.1128/MCB.20.10.3742-3751.2000. PMC 85678. PMID 10779363.
- ↑ Ago T, Sadoshima J (2006). "GDF15, a cardioprotective TGF-beta superfamily protein". Circ Res 98 (3): 294–297. doi:10.1161/01.RES.0000207919.83894.9d. PMID 16484622.
External links
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