GDF10

From Wikipedia, the free encyclopedia
Growth differentiation factor 10
Identifiers
SymbolsGDF10; BMP-3b; BMP3B
External IDsOMIM: 601361 MGI: 95684 HomoloGene: 3640 GeneCards: GDF10 Gene
Orthologs
SpeciesHumanMouse
Entrez266214560
EnsemblENSG00000107623ENSMUSG00000021943
UniProtP55107P97737
RefSeq (mRNA)NM_004962NM_145741
RefSeq (protein)NP_004953NP_665684
Location (UCSC)Chr 10:
48.43 – 48.44 Mb
Chr 14:
33.92 – 33.94 Mb
PubMed search

Growth differentiation factor 10 (GDF10) also known as bone morphogenetic protein 3B (BMP-3B) is a protein that in humans is encoded by the GDF10 gene.[1]

GDF10 belongs to the transforming growth factor beta superfamily that is closely related to bone morphogenetic protein-3 (BMP3). It plays a role in head formation and may have multiple roles in skeletal morphogenesis.[2][1] GDF10 is also known as BMP-3b, with GDF10 and BMP3 regarded as a separate subgroup within the TGF-beta superfamily.[1]

In mice, GDF10 mRNA is abundant in the brain, inner ear, uterus, prostate, neural tissues, blood vessels and adipose tissue with low expression in spleen and liver. It is also present in bone of both adults and neonatal mice.[1] Human GDF10 mRNA is found in the cochlea and lung of foetuses, and in testis, retina, pineal gland, and other neural tissues of adults.[3]

References

  1. 1.0 1.1 1.2 1.3 Cunningham NS, Jenkins NA, Gilbert DJ, Copeland NG, Reddi AH, Lee SJ (1995). "Growth/differentiation factor-10: a new member of the transforming growth factor-beta superfamily related to bone morphogenetic protein-3". Growth Factors 12 (2): 99–109. doi:10.3109/08977199509028956. PMID 8679252. 
  2. Hino J, Kangawa K, Matsuo H, Nohno T, Nishimatsu S (2004). "Bone morphogenetic protein-3 family members and their biological functions". Front Biosci 9: 1520–9. doi:10.2741/1355. PMID 14977563. 
  3. Katoh Y, Katoh M (2006). "Comparative integromics on BMP/GDF family". Int J Mol Med 17 (5): 951–5. PMID 16596286. 


Further reading

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