Fursultiamine

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Fursultiamine
Systematic (IUPAC) name
N-[(4-amino-2-methylpyrimidin-5-yl)methyl]-N-{(1E)-4-hydroxy-1-methyl-2-[(tetrahydrofuran-2-ylmethyl)disulfanyl]but-1-en-1-yl}formamide
Clinical data
AHFS/Drugs.com International Drug Names
Legal status OTC
Routes Oral
Identifiers
CAS number 804-30-8
ATC code None
PubChem CID 3002119
ChemSpider 2273321
UNII 05J61265PX YesY
Chemical data
Formula C17H26N4O3S2 
Mol. mass 398.54 g/mol

Fursultiamine (INN; Adventan, Alinamin-F, Benlipoid, Bevitol Lipophil, Judolor), also known as thiamine tetrahydrofurfuryl disulfide (TTFD), is a disulfide derivative of thiamine, or an allithiamine.[1] It was synthesized in Japan in the 1960s for the purpose of developing forms of thiamine with improved lipophilicity for treating vitamin B1 deficiency (i.e., beriberi),[1][2] and was subsequently commercialized not only in Japan but also in Spain, Austria, Germany, and the United States.[3] As a vitamin, it is available over-the-counter as well.[4]

In addition to its clinical indication of avitaminosis, fursultiamine has been studied in clinical trials for Alzheimer's disease and autistic spectrum disorders with positive but modest benefits.[5][6] It has also been investigated in improving energy metabolism during exercise and reducing exercise-induced fatigue with conflicting results.[4][7][8][9]

Available Brands: Privitamix softgel (India)

See also

References

  1. ↑ 1.0 1.1 Lonsdale D (September 2004). "Thiamine tetrahydrofurfuryl disulfide: a little known therapeutic agent". Medical Science Monitor : International Medical Journal of Experimental and Clinical Research 10 (9): RA199–203. PMID 15328496. 
  2. ↑ Miura S (July 1965). "[The uptake and the distribution of thiamine propyl disulfide-35S by the rabbit's eye tissue]". Nippon Ganka Gakkai Zasshi (in Japanese) 69 (7): 792–807, discussion 807–8. PMID 5006719. 
  3. ↑ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. p. 1932. ISBN 3-88763-075-0. 
  4. ↑ 4.0 4.1 Nozaki S, Mizuma H, Tanaka M, et al. (December 2009). "Thiamine tetrahydrofurfuryl disulfide improves energy metabolism and physical performance during physical-fatigue loading in rats". Nutrition Research (New York, N.Y.) 29 (12): 867–72. doi:10.1016/j.nutres.2009.10.007. PMID 19963160. 
  5. ↑ Mimori Y, Katsuoka H, Nakamura S (March 1996). "Thiamine therapy in Alzheimer's disease". Metabolic Brain Disease 11 (1): 89–94. doi:10.1007/BF02080934. PMID 8815393. 
  6. ↑ Lonsdale D, Shamberger RJ, Audhya T (August 2002). "Treatment of autism spectrum children with thiamine tetrahydrofurfuryl disulfide: a pilot study". Neuro Endocrinology Letters 23 (4): 303–8. PMID 12195231. 
  7. ↑ Suzuki M, Itokawa Y (March 1996). "Effects of thiamine supplementation on exercise-induced fatigue". Metabolic Brain Disease 11 (1): 95–106. PMID 8815395. 
  8. ↑ Webster MJ, Scheett TP, Doyle MR, Branz M (1997). "The effect of a thiamin derivative on exercise performance". European Journal of Applied Physiology and Occupational Physiology 75 (6): 520–4. PMID 9202948. 
  9. ↑ Masuda H, Matsumae H, Masuda T, Hatta H (2010). "A thiamin derivative inhibits oxidation of exogenous glucose at rest, but not during exercise". Journal of Nutritional Science and Vitaminology 56 (1): 9–12. PMID 20354340. 

Further reading

Fat soluble
Water soluble
Combinations

M: NUT

cof, enz, met

noco, nuvi, sysi/epon, met

drug (A8/11/12)

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