Formetamide
| Formetamide | ||
|---|---|---|
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| IUPAC name N-(1-Phenylpropan-2-yl)formamide | ||
| Other names Formetorex | ||
| Identifiers | ||
| PubChem | 65614 | |
| ChemSpider | 59055 | |
| Jmol-3D images | Image 1 | |
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| Properties | ||
| Molecular formula | C10H13NO | |
| Molar mass | 163.22 g mol−1 | |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | ||
| Infobox references | ||
Formetamide or N-formylamphetamine is an intermediate in the production of amphetamine by the "Leuckart reaction."[1] It is also commonly found as an impurity in clandestine labs where this synthesis method is used.[1][2] Due to the simplicity of the Leuckart reaction, it is the most popular synthetic route employed for the illicit manufacture of amphetamines.[1] The synthesis involves a non-metal reduction that is typically carried out in three steps.[1] For amphetamine synthesis, a mixture of phenylacetone and formamide (sometimes in the presence of formic acid) or ammonium formate, is heated until a condensation reaction results in the intermediate product, formetatide.[1] In the second step, formetamide is hydrolysed using hydrochloric acid, and the reaction mixture is then basified, isolated, and steam distilled to produce the free base.[1] The final step, the product is dissolved in an organic solvent and precipitated as the sulphate salt of amphetamine by adding sulfuric acid.[1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Laboratory and Scientific Section (2006). Recommended methods of the identification and analysis of amphetamine, methamphetamine, and their ring-substituted analogues in seized materials. New York: United Nations Office on Drugs and Crime Vienna. ISBN 92-1-148208-9. Retrieved 14 October 2013.
- ↑ Kram, TC (July 1979). "Reidentification of a major impurity in illicit amphetamine.". Journal of forensic sciences 24 (3): 596–9. PMID 541629.
External links
- formetamide at the US National Library of Medicine Medical Subject Headings (MeSH)
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