Focal proliferative nephritis

From Wikipedia, the free encyclopedia

Focal proliferative nephritis is a type of glomerulonephritis seen in 20% to 35% of cases of SLE, classified as type III SLE. As the name suggests, lesions are visualized in only portions of fewer than half the glomeruli. Typically, one or two foci within an otherwise normal glomerulus show swelling and proliferation of endothelial and mesangial cells, infiltration by neutrophils, and/or fibrinoid deposits with capillary thrombi. Focal glomerulonephritis is usually associated with only mild microscopic hematuria and proteinuria; a transition to a more diffuse form of renal involvement is associated with more severe disease.^[1]

References

↑ Robbins, Stanley L.; Kumar, Vinay (2007). Robbins basic pathology. Saunders/Elsevier. p. 142. ISBN 0-8089-2366-8.

v t e Lupus nephritis

Class I (Minimal mesangial glomerulonephritis) Class II (Mesangial proliferative lupus nephritis) Class III (Focal proliferative nephritis) Class IV (Diffuse proliferative nephritis) Class V (Membranous nephritis) Class VI (Glomerulosclerosis)

Urinary system
Pathology
Urologic disease / Uropathy (N00–N39, 580–599)

Abdominal

Nephropathy/
(nephritis+
nephrosis)

Glomerulopathy/
glomerulitis/
(glomerulonephritis+
glomerulonephrosis)

Primarily
nephrotic

Non-proliferative	Minimal change Focal segmental Membranous

Proliferative	Mesangial proliferative Endocapillary proliferative Membranoproliferative/mesangiocapillary

By condition	Diabetic Amyloidosis

Primarily
nephritic,
RPG

Type I RPG/Type II hypersensitivity	Goodpasture's syndrome

Type II RPG/Type III hypersensitivity	Post-streptococcal Lupus DPN IgA/Berger's

Type III RPG/Pauci-immune	Granulomatosis with polyangiitis Microscopic polyangiitis Churg–Strauss syndrome

Tubulopathy/
tubulitis

Proximal	RTA RTA 2 Fanconi syndrome

Thick ascending	Bartter syndrome

Distal convoluted	Gitelman syndrome

Collecting duct	Liddle's syndrome RTA RTA 1 Diabetes insipidus Nephrogenic

Renal papilla	Renal papillary necrosis

Major calyx/pelvis	Hydronephrosis Pyonephrosis Reflux nephropathy

Any/all	Acute tubular necrosis

Interstitium

Interstitial nephritis
- Pyelonephritis
- Danubian endemic familial nephropathy

Any/all

General syndromes	Renal failure Acute renal failure Chronic kidney disease Uremic pericarditis Uremia

Vascular	Renal artery stenosis Renal ischemia Hypertensive nephropathy Renovascular hypertension Renal cortical necrosis

Other	Analgesic nephropathy Renal osteodystrophy Nephroptosis Abderhalden–Kaufmann–Lignac syndrome

Ureter

Pelvic

Bladder	Cystitis Interstitial cystitis Hunner's ulcer Trigonitis Hemorrhagic cystitis Neurogenic bladder dysfunction Bladder sphincter dyssynergia Vesicointestinal fistula Vesicoureteral reflux

Urethra	Urethritis Non-gonococcal urethritis Urethral syndrome Urethral stricture/Meatal stenosis Urethral caruncle

Any/all

M: URI

anat/phys/devp/cell

noco/acba/cong/tumr, sysi/epon, urte

proc/itvp, drug (G4B), blte, urte

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