Flufenamic acid

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Flufenamic acid
Systematic (IUPAC) name
2-{[3-(Trifluoromethyl)phenyl]amino}benzoic acid
Clinical data
AHFS/Drugs.com International Drug Names
Legal status Prescription Only (S4) (AU)
Routes oral, topical
Pharmacokinetic data
Protein binding extensively
Metabolism Hydroxylation, glucuronidation
Half-life ~3 h
Excretion 50% urine, 36% feces
Identifiers
CAS number 530-78-9
ATC code M01AG03
PubChem CID 3371
IUPHAR ligand 2447
DrugBank DB02266
ChemSpider 3254 YesY
UNII 60GCX7Y6BH YesY
KEGG D01581 YesY
ChEBI CHEBI:42638 YesY
ChEMBL CHEMBL23588 YesY
Chemical data
Formula C14H10F3NO2 
Mol. mass 281.22991 g/mol
Physical data
Melt. point 124–125 °C (255–257 °F) resolidification and remelting at 134°C to 136°C
Solubility in water Practically insoluble in water; soluble in ethanol, chloroform and diethyl ether mg/mL (20 °C)
 YesY (what is this?)  (verify)

Flufenamic acid, also known as Fluffy or Fluf[citation needed], is a non-steroidal anti-inflammatory drug.[1] It is pale yellow crystalline powder.

Flufenamic acid also blocks voltage-gated sodium channels responsible for the depolarising after-potential (DAP) that underlies phasic firing in the phasic firing of magnocellular neurons in the supraoptic and paraventricular nuclei.[citation needed]

References

  1. ↑ Lovering, A. L.; Ride, J. P.; Bunce, C. M.; Desmond, J. C.; Cummings, S. M.; White, S. A. (2004). "Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin". Cancer research 64 (5): 1802–1810. PMID 14996743. 
Non-steroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A, also N02BA)
Pyrazolidines
Salicylates
Acetic acid derivatives
and related substances
Oxicams
Propionic acid derivatives
(profens)
N-Arylanthranilic acids
(fenamates)
Coxibs
Other
Items listed in bold indicate initially developed compounds of specific groups. †Withdrawn drugs. ‡Veterinary use medications.

M: MUS, DF+DRCT

anat (h/n, u, t/d, a/p, l)/phys/devp/hist

noco (m, s, c)/cong (d)/tumr, sysi/epon, injr

proc, drug (M1A/3)

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