Flavokavain A

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Flavokavain A
IUPAC name

(E)-3-(4-methoxyphenyl)-1-(2,4-bismethoxy-6-hydroxyphenyl)propenone

Other names

2'-hydroxy-4,4',6'-trimethoxychalcone
Flavokawain A

Identifiers
CAS number 37951-13-6 YesY
PubChem 5355469
Beilstein Reference 2224776
Jmol-3D images Image 1
Properties
Molecular formula C18H18O5
Molar mass 314.33 g mol−1
 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Flavokavain A is a flavokavain found in the kava plant.[1] It induces apoptosis in bladder cancer cells via a Bax protein-dependent and mitochondria-dependent apoptotic pathway.[2]

See also

References

  1. ↑ Dharmaratne, H. Ranjith W.; N. P. Dhammika Nanayakkara, Ikhlas A. Khan (February 2002). "Kavalactones from Piper methysticum, and their 13C NMR spectroscopic analyses". Phytochemistry 59 (4): 429–33. doi:10.1016/S0031-9422(01)00443-5. PMID 11830162. 
  2. ↑ Zi X, Simoneau AR. "Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice.". Cancer Research. PMID 15833884. 

External links

History
Chemical composition
Chalconoids and their glycosides
Chalconoids
Chalconoid glycosides
  • Carthamin
  • Marein
  • okanin 3,4,3′-trimethyl ether 4′-glucoside
  • okanin 4-methyl ether 4′-glucoside
  • okanin 4-methyl ether 4′-glucoside monoacetate
  • Okanin 3,4-dimethyl ether 4′-glucoside
Acetylated chalconoids
O-methylated chalconoids
  • Cardamomin
  • Okanin 3,4,3′,4′-tetramethyl ether
Flavokavains
Synthetic


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