Fesoterodine
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|---|---|
| Systematic (IUPAC) name | |
| [2-[(1R)-3-(Di(propan-2-yl)amino)-1-phenylpropyl]-4-(hydroxymethyl)phenyl] 2-methylpropanoate | |
| Clinical data | |
| Trade names | Toviaz |
| AHFS/Drugs.com | monograph |
| MedlinePlus | a609021 |
| Licence data | EMA:Link, US FDA:link |
| Pregnancy cat. | C (US) |
| Legal status | ℞ Prescription only |
| Routes | Oral |
| Pharmacokinetic data | |
| Bioavailability | 52% (active metabolite) |
| Protein binding | 50% (active metabolite) |
| Metabolism | Hepatic (CYP2D6- and 3A4-mediated) |
| Half-life | 7–8 hours (active metabolite) |
| Excretion | Renal (70%) and fecal (7%) |
| Identifiers | |
| CAS number | 286930-03-8  |
| ATC code | G04BD11 |
| PubChem | CID 6918558 |
| DrugBank | DB06702 |
| ChemSpider | 5293755  |
| UNII | 621G617227 |
| KEGG | D07226 |
| ChEMBL | CHEMBL1201764 |
| Chemical data | |
| Formula | C26H37NO3 |
| Mol. mass | 411.278 g/mol |
| SMILES
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Fesoterodine (INN, used as the fumarate under the brand name Toviaz) is an antimuscarinic drug developed by Schwarz Pharma AG to treat overactive bladder syndrome (OAB).[1] It was approved by the European Medicines Agency in April 2007,[2] the US Food and Drug Administration on October 31, 2008 [3] and Health Canada on February 9, 2012.[4]
Fesoterodine is a prodrug. It is broken down into its active metabolite, 5-hydroxymethyl tolterodine, by plasma esterases.
Efficacy
Fesoterodine has the advantage of allowing more flexible dosage than other muscarinic antagonists.[5] Its tolerability and side effects are similar to other muscarinic antagonists and as a new drug seems unlikely to make great changes in practices of treatment for overactive bladder.[5]
References
- ↑ "Fesoterodine, New Drug Candidate For Treatment For Overactive Bladder – Pfizer To Acquire Exclusive Worldwide Rights". Medical News Today. 17 April 2006.
- ↑ "Toviaz: European Public Assessment Report, Revision 3 - Published 02/06/08". European Medicines Agency. 2 June 2008.
- ↑ "Pfizer's Toviaz (fesoterodine fumarate) Receives FDA Approval for the Treatment of Overactive Bladder" (Press release). Pfizer Inc. 2008-10-31. Retrieved 2008-11-06.
- ↑ Notice of Decision for TOVIAZ
- ↑ 5.0 5.1 Vella, M.; Cardozo, L. (2011). "Review of fesoterodine". Expert Opinion on Drug Safety 10 (5): 805–808. doi:10.1517/14740338.2011.591377. PMID 21639817.
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