FasX small RNA
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In molecular biology, the FasX small RNA (fibronectin/fibrinogen-binding/haemolytic-activity/streptokinase-regulator-X) is a small RNA (sRNA) produced by species of Streptococcus.[1] FasX regulates expression of secreted virulence factor streptokinase (SKA), encoded by the ska gene. FasX base pairs to the 5' end of the ska mRNA, and increases mRNA stability resulting in increased levels of SKA.[2] FasX negatively regulates the expression of pili on the bacterial cell surface. It binds to, reduces the stability of and inhibits translation from the pilus biosynthesis operon mRNA.[3]
See also
References
- ↑ Kreikemeyer, B; Boyle, MD; Buttaro, BA; Heinemann, M; Podbielski, A (2001 Jan). "Group A streptococcal growth phase-associated virulence factor regulation by a novel operon (Fas) with homologies to two-component-type regulators requires a small RNA molecule.". Molecular microbiology 39 (2): 392–406. PMID 11136460.
- ↑ Ramirez-Peña, E; Treviño, J; Liu, Z; Perez, N; Sumby, P (2010 Dec). "The group A Streptococcus small regulatory RNA FasX enhances streptokinase activity by increasing the stability of the ska mRNA transcript.". Molecular microbiology 78 (6): 1332–47. doi:10.1111/j.1365-2958.2010.07427.x. PMC 3071709. PMID 21143309.
- ↑ Liu, Z; Treviño, J; Ramirez-Peña, E; Sumby, P (2012 Oct). "The small regulatory RNA FasX controls pilus expression and adherence in the human bacterial pathogen group A Streptococcus.". Molecular microbiology 86 (1): 140–54. doi:10.1111/j.1365-2958.2012.08178.x. PMID 22882718.
Further reading
- Le Rhun, A; Charpentier, E (2012 Apr). "Small RNAs in streptococci.". RNA biology 9 (4): 414–26. doi:10.4161/rna.20104. PMID 22546939.
- Podkaminski, D; Vogel, J (2010 Dec). "Small RNAs promote mRNA stability to activate the synthesis of virulence factors.". Molecular microbiology 78 (6): 1327–31. doi:10.1111/j.1365-2958.2010.07428.x. PMID 21143308.
- Siller, M; Janapatla, RP; Pirzada, ZA; Hassler, C; Zinkl, D; Charpentier, E (2008 Oct 30). "Functional analysis of the group A streptococcal luxS/AI-2 system in metabolism, adaptation to stress and interaction with host cells.". BMC microbiology 8: 188. doi:10.1186/1471-2180-8-188. PMC 2603038. PMID 18973658.
- Steiner, K; Malke, H (2002 Jul). "Dual control of streptokinase and streptolysin S production by the covRS and fasCAX two-component regulators in Streptococcus dysgalactiae subsp. equisimilis.". Infection and immunity 70 (7): 3627–36. PMC 128039. PMID 12065504.
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