FKBP3
From Wikipedia, the free encyclopedia
| FK506 binding protein 3, 25kDa | |||||||||||||
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 PDB rendering based on 1pbk. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | FKBP3; FKBP-25; FKBP-3; FKBP25; PPIase | ||||||||||||
| External IDs | OMIM: 186947 MGI: 1353460 HomoloGene: 1525 ChEMBL: 4746 GeneCards: FKBP3 Gene | ||||||||||||
| EC number | 5.2.1.8 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 2287 | 30795 | |||||||||||
| Ensembl | ENSG00000100442 | ENSMUSG00000020949 | |||||||||||
| UniProt | Q00688 | Q62446 | |||||||||||
| RefSeq (mRNA) | NM_002013 | NM_013902 | |||||||||||
| RefSeq (protein) | NP_002004 | NP_038930 | |||||||||||
| Location (UCSC) | Chr 14: 45.58 – 45.6 Mb | Chr 12: 65.06 – 65.07 Mb | |||||||||||
| PubMed search | |||||||||||||
FK506-binding protein 3 is a protein that in humans is encoded by the FKBP3 gene.[1][2][3]
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.[3]
Interactions
FKBP3 has been shown to interact with YY1,[4] HDAC1,[4] Histone deacetylase 2[4] and Mdm2.[5]
References
- ↑ Hung DT, Schreiber SL (Jun 1992). "cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein". Biochem Biophys Res Commun 184 (2): 733–8. doi:10.1016/0006-291X(92)90651-Z. PMID 1374240.
- ↑ Porat R, Poutsiaka DD, Miller LC, Granowitz EV, Dinarello CA (May 1992). "Interleukin-1 (IL-1) receptor blockade reduces endotoxin and Borrelia burgdorferi-stimulated IL-8 synthesis in human mononuclear cells". FASEB J 6 (7): 2482–6. PMID 1532945.
- ↑ 3.0 3.1 "Entrez Gene: FKBP3 FK506 binding protein 3, 25kDa".
- ↑ 4.0 4.1 4.2 Yang, W M; Yao Y L, Seto E (Sep 2001). "The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1". EMBO J. (England) 20 (17): 4814–25. doi:10.1093/emboj/20.17.4814. ISSN 0261-4189. PMC 125595. PMID 11532945.
- ↑ Ochocka, Anna Maria; Kampanis Petros, Nicol Samantha, Allende-Vega Nerea, Cox Miranda, Marcar Lynnette, Milne Diane, Fuller-Pace Frances, Meek David (Feb 2009). "FKBP25, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53". FEBS Lett. (Netherlands) 583 (4): 621–6. doi:10.1016/j.febslet.2009.01.009. PMID 19166840.
Further reading
- Jin YJ, Burakoff SJ, Bierer BE (1992). "Molecular cloning of a 25-kDa high affinity rapamycin binding protein, FKBP25". J. Biol. Chem. 267 (16): 10942–5. PMID 1375932.
- Wiederrecht G, Martin MM, Sigal NH, Siekierka JJ (1992). "Isolation of a human cDNA encoding a 25 kDa FK-506 and rapamycin binding protein". Biochem. Biophys. Res. Commun. 185 (1): 298–303. doi:10.1016/S0006-291X(05)80990-8. PMID 1376117.
- Jin YJ, Burakoff SJ (1993). "The 25-kDa FK506-binding protein is localized in the nucleus and associates with casein kinase II and nucleolin". Proc. Natl. Acad. Sci. U.S.A. 90 (16): 7769–73. doi:10.1073/pnas.90.16.7769. PMC 47224. PMID 7689229.
- Cross SH, Charlton JA, Nan X, Bird AP (1994). "Purification of CpG islands using a methylated DNA binding column". Nat. Genet. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID 8012384.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Yang WM, Yao YL, Seto E (2001). "The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1". EMBO J. 20 (17): 4814–25. doi:10.1093/emboj/20.17.4814. PMC 125595. PMID 11532945.
- Meng X, Chen J, Yang Q, et al. (2003). "Cloning and identification of a novel cDNA which may be associated with FKBP25". Biochem. Genet. 40 (9–10): 303–10. doi:10.1023/A:1020256718720. PMID 12392168.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
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