FHL3
From Wikipedia, the free encyclopedia
| Four and a half LIM domains 3 | |||||||||||||
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 PDB rendering based on 1wyh. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | FHL3; SLIM2 | ||||||||||||
| External IDs | OMIM: 602790 MGI: 1341092 HomoloGene: 37928 GeneCards: FHL3 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 2275 | 14201 | |||||||||||
| Ensembl | ENSG00000183386 | ENSMUSG00000032643 | |||||||||||
| UniProt | Q13643 | Q9R059 | |||||||||||
| RefSeq (mRNA) | NM_001243878 | NM_010213 | |||||||||||
| RefSeq (protein) | NP_001230807 | NP_034343 | |||||||||||
| Location (UCSC) | Chr 1: 38.46 – 38.47 Mb | Chr 4: 124.7 – 124.71 Mb | |||||||||||
| PubMed search | |||||||||||||
Four and a half LIM domains protein 3 is a protein that in humans is encoded by the FHL3 gene.[1][2][3]
LIM proteins are defined by the possession of a highly conserved double zinc finger motif called the LIM domain.[supplied by OMIM][3]
Interactions
FHL3 has been shown to interact with FHL2,[4][5] CTBP2,[6] KLF3,[6] ITGA7[7] and CREB1.[4]
References
- ↑ Morgan MJ, Madgwick AJ (October 1996). "Slim defines a novel family of LIM-proteins expressed in skeletal muscle". Biochem Biophys Res Commun 225 (2): 632–8. doi:10.1006/bbrc.1996.1222. PMID 8753811.
- ↑ Lee SM, Tsui SK, Chan KK, Kotaka M, Li HY, Chim SS, Waye MM, Fung KP, Lee CY (May 1999). "Chromosomal mapping of a skeletal muscle specific LIM-only protein FHL3 to the distal end of the short arm of human chromosome 1". Somat Cell Mol Genet 24 (3): 197–202. doi:10.1023/B:SCAM.0000007122.03392.4b. PMID 10226657.
- ↑ 3.0 3.1 "Entrez Gene: FHL3 four and a half LIM domains 3".
- ↑ 4.0 4.1 Fimia, G M; De Cesare D, Sassone-Corsi P (November 2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Mol. Cell. Biol. (UNITED STATES) 20 (22): 8613–22. doi:10.1128/MCB.20.22.8613-8622.2000. ISSN 0270-7306. PMC 102166. PMID 11046156.
- ↑ Li, H Y; Ng E K, Lee S M, Kotaka M, Tsui S K, Lee C Y, Fung K P, Waye M M (2001). "Protein-protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins (GFP) two-fusion fluorescence resonance energy transfer (FRET)". J. Cell. Biochem. (United States) 80 (3): 293–303. doi:10.1002/1097-4644(20010301)80:3<293::AID-JCB10>3.0.CO;2-U. ISSN 0730-2312. PMID 11135358.
- ↑ 6.0 6.1 Turner, Jeremy; Nicholas Hannah, Bishop David, Matthews Jacqueline M, Crossley Merlin (April 2003). "The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2". J. Biol. Chem. (United States) 278 (15): 12786–95. doi:10.1074/jbc.M300587200. ISSN 0021-9258. PMID 12556451.
- ↑ Samson, Thomas; Smyth Neil, Janetzky Stefanie, Wendler Olaf, Müller Judith M, Schüle Roland, von der Mark Helga, von der Mark Klaus, Wixler Viktor (July 2004). "The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor". J. Biol. Chem. (United States) 279 (27): 28641–52. doi:10.1074/jbc.M312894200. ISSN 0021-9258. PMID 15117962.
Further reading
- Morgan MJ, Madgwick AJ (1999). "The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle.". Biochem. Biophys. Res. Commun. 255 (2): 245–50. doi:10.1006/bbrc.1999.0179. PMID 10049693.
- Li HY, Ng EK, Lee SM, et al. (2001). "Protein-protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins (GFP) two-fusion fluorescence resonance energy transfer (FRET).". J. Cell. Biochem. 80 (3): 293–303. doi:10.1002/1097-4644(20010301)80:3<293::AID-JCB10>3.0.CO;2-U. PMID 11135358.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Turner J, Nicholas H, Bishop D, et al. (2003). "The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2.". J. Biol. Chem. 278 (15): 12786–95. doi:10.1074/jbc.M300587200. PMID 12556451.
- Mils V, Lee SM, Joly W, et al. (2003). "LIM-only protein FHL3 interacts with CDC25B2 phosphatase.". Exp. Cell Res. 285 (1): 99–106. doi:10.1016/S0014-4827(03)00018-1. PMID 12681290.
- Coghill ID, Brown S, Cottle DL, et al. (2003). "FHL3 is an actin-binding protein that regulates alpha-actinin-mediated actin bundling: FHL3 localizes to actin stress fibers and enhances cell spreading and stress fiber disassembly.". J. Biol. Chem. 278 (26): 24139–52. doi:10.1074/jbc.M213259200. PMID 12704194.
- Purcell NH, Darwis D, Bueno OF, et al. (2004). "Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes.". Mol. Cell. Biol. 24 (3): 1081–95. doi:10.1128/MCB.24.3.1081-1095.2004. PMC 321437. PMID 14729955.
- Samson T, Smyth N, Janetzky S, et al. (2004). "The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor.". J. Biol. Chem. 279 (27): 28641–52. doi:10.1074/jbc.M312894200. PMID 15117962.
- Takahashi K, Matsumoto C, Ra C (2005). "FHL3 negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF-1.". Biochem. J. 386 (Pt 1): 191–200. doi:10.1042/BJ20040775. PMC 1134781. PMID 15453830.
- Philippar U, Schratt G, Dieterich C, et al. (2005). "The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF.". Mol. Cell 16 (6): 867–80. doi:10.1016/j.molcel.2004.11.039. PMID 15610731.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Cottle DL, McGrath MJ, Cowling BS, et al. (2007). "FHL3 binds MyoD and negatively regulates myotube formation.". J. Cell. Sci. 120 (Pt 8): 1423–35. doi:10.1242/jcs.004739. PMID 17389685.
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External links
- FHL3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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