FBXO32

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F-box protein 32
Identifiers
SymbolsFBXO32; Fbx32; MAFbx
External IDsOMIM: 606604 MGI: 1914981 HomoloGene: 12182 GeneCards: FBXO32 Gene
Orthologs
SpeciesHumanMouse
Entrez11490767731
EnsemblENSG00000156804ENSMUSG00000022358
UniProtQ969P5Q9CPU7
RefSeq (mRNA)NM_001242463NM_026346
RefSeq (protein)NP_001229392NP_080622
Location (UCSC)Chr 8:
124.51 – 124.55 Mb
Chr 15:
58.18 – 58.21 Mb
PubMed search

F-box only protein 32 is a protein that in humans is encoded by the FBXO32 gene.[1][2][3]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing of this gene results in two transcript variants encoding two isoforms of different sizes.[3]

Interactions

FBXO32 has been shown to interact with EIF3A.[4]

References

  1. Bodine SC, Latres E, Baumhueter S, Lai VK, Nunez L, Clarke BA, Poueymirou WT, Panaro FJ, Na E, Dharmarajan K, Pan ZQ, Valenzuela DM, DeChiara TM, Stitt TN, Yancopoulos GD, Glass DJ (Nov 2001). "Identification of ubiquitin ligases required for skeletal muscle atrophy". Science 294 (5547): 1704–8. doi:10.1126/science.1065874. PMID 11679633. 
  2. Gomes MD, Lecker SH, Jagoe RT, Navon A, Goldberg AL (Dec 2001). "Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy". Proc Natl Acad Sci U S A 98 (25): 14440–5. doi:10.1073/pnas.251541198. PMC 64700. PMID 11717410. 
  3. 3.0 3.1 "Entrez Gene: FBXO32 F-box protein 32". 
  4. Lagirand-Cantaloube, Julie; Offner Nicolas, Csibi Alfredo, Leibovitch Marie P, Batonnet-Pichon Sabrina, Tintignac Lionel A, Segura Carlos T, Leibovitch Serge A (Apr 2008). "The initiation factor eIF3-f is a major target for atrogin1/MAFbx function in skeletal muscle atrophy". EMBO J. (England) 27 (8): 1266–76. doi:10.1038/emboj.2008.52. PMC 2367397. PMID 18354498. 

Further reading


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