Ezetimibe/atorvastatin

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Ezetimibe/atorvastatin
Combination of
Ezetimibe Hypolipidemic agent
Atorvastatin Statin
Clinical data
Legal status ?
Identifiers
ATC code C10BA05

Ezetimibe/atorvastatin (brand name Liptruzet) is a cholesterol lowering combination drug. In the United States, it was approved in May 2013 by the Food and Drug Administration for the treatment of elevated low-density lipoprotein (LDL) in patients with primary or mixed hyperlipidemia as adjunctive therapy to diet.[1]

Some cardiologists opposed the approval, because the combination reduced LDL cholesterol in a clinical trial, it did not reduce heart disease. A clinical trial with the endpoints of heart attacks, strokes and heart-related deaths is scheduled to conclude in 2014.[2]

References

  1. ↑ "FDA Approves Merck’s LIPTRUZET™ (ezetimibe and atorvastatin), a New Product That Can Help Powerfully Lower LDL Cholesterol". Business Wire. May 06, 2013. Retrieved May 06, 2013. 
  2. ↑ Drug to Cut Cholesterol Is Approved by the F.D.A. By KATIE THOMAS, New York Times, May 3, 2013
Lipid modifying agents (C10)
GI tract
Cholesterol absorption inhibitors, NPC1L1
  • Ezetimibe
  • SCH-48461
Bile acid sequestrants/resins (LDL)
  • Cholestyramine
  • Colestipol
  • Colestilan
  • Colextran
  • Colesevelam
Liver
Statins (HMG-CoA reductase, LDL)
  • Simvastatin#
  • Atorvastatin
  • Fluvastatin
  • Lovastatin
  • Mevastatin
  • Pitavastatin
  • Pravastatin
  • Rosuvastatin
  • Cerivastatin‡
Niacin and derivatives (HDL and LDL)
  • Niceritrol
  • Niacin
  • Nicofuranose
  • Aluminium nicotinate
  • Nicotinyl alcohol
  • Acipimox
MTTP inhibitors (VLDL)
  • Dirlotapide
  • Lomitapide
  • Mitratapide
Blood vessels
Fibrates (PPAR)
  • Clofibrate‡
  • Bezafibrate
  • Aluminium clofibrate
  • Gemfibrozil
  • Fenofibrate
  • Simfibrate
  • Ronifibrate
  • Ciprofibrate
  • Etofibrate
  • Clofibride
  • Clinofibrate
CETP inhibitors (HDL)
  • Anacetrapib†
  • Dalcetrapib§
  • Evacetrapib§
  • Torcetrapib†
Combinations
  • Niacin/lovastatin
  • Niacin/simvastatin
  • Ezetimibe/simvastatin
  • Ezetimibe/atorvastatin
  • Niacin/laropiprant
Other
  • Dextrothyroxine‡
  • Probucol
  • Tiadenol
  • Benfluorex
  • Meglutol
  • Omega-3-triglycerides
  • Magnesium pyridoxal 5-phosphate glutamate
  • Policosanol
  • Lapaquistat§
  • Mipomersen
  • Alipogene tiparvovec
  • #WHO-EM
  • ‡Withdrawn from market
  • Clinical trials:
    • †Phase III
    • §Never to phase III

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