Epithelioid sarcoma
From Wikipedia, the free encyclopedia
| Epithelioid sarcoma | |
|---|---|
| Classification and external resources | |
 Micrograph of an epithelioid sarcoma. H&E stain. | |
| ICD-O: | M8804/3 |
Epithelioid sarcoma is a rare mesenchymal soft tissue tumour with an epithelioid pattern. It often occurs in the extremities, and is more commonly found in young adults.[1]
Diagnosis
The diagnosis is made by examination of tissue, e.g. a biopsy. The diagnosis may be delayed because of the unusual nature of the tumour and its rarity. Its histomorphology near perfectly may mimic an adenocarcinoma, melanoma or granuloma.
Their immunohistochemical profile may mimic those of carcinomas; thus, these tumours may be misdiagnosed as such.
They typically stain for vimentin and keratins. They characteristically have loss of staining for SMARCB1 (INI1, BAF47), and typically stain for CA125.[2]
See also
- Sarcoma
- Malignant rhabdoid tumour
- Atypical teratoid/rhabdoid tumour
Additional images
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Intermed. mag.
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High mag.
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High mag. (SMARCB1)
References
- ↑ Miettinen, M.; Fanburg-Smith, JC.; Virolainen, M.; Shmookler, BM.; Fetsch, JF. (Aug 1999). "Epithelioid sarcoma: an immunohistochemical analysis of 112 classical and variant cases and a discussion of the differential diagnosis.". Hum Pathol 30 (8): 934–42. PMID 10452506.
- ↑ Kato H, Hatori M, Kokubun S, et al. (March 2004). "CA125 expression in epithelioid sarcoma". Jpn. J. Clin. Oncol. 34 (3): 149–54. PMID 15078911.
External links
- Epithelioid Sarcoma by Pooya Hosseinzadeh, MD and Felix Cheung, MD
- The Doctors' Doctor, accessed January 3 2008
- My Left Hand, documentary film about one man's battle with epithelioid sarcoma
- Archives of Pathology & Laboratory Medicine, Sep 2003, accessed January 3 2008
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