Epi-lipoxin

From Wikipedia, the free encyclopedia

Epi-lipoxins are the 5R-epimers of lipoxins. These nonclassic eicosanoids are formed in vivo, in the presence of aspirin.[1] They play a counter-regulatory role in inflammation, serving as a stop signal.[2]

References

  1. ↑ Clària J, Serhan CN (1995). "Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9475–9. doi:10.1073/pnas.92.21.9475. PMC 40824. PMID 7568157. Retrieved 2007-11-01. 
  2. ↑ Serhan CN (2001). "Lipoxins and aspirin-triggered 15-epi-lipoxins are endogenous components of antiinflammation: emergence of the counterregulatory side". Arch. Immunol. Ther. Exp. (Warsz.) 49 (3): 177–88. PMID 11478391. 
Precursor
Prostanoids
Prostaglandins (PG) and
analogues
Precursor
Active
D/J
E/F
I
Thromboxanes (TX)
Leukotrienes (LT)
Precursor
Initial
SRS-A
Nonclassic
By function

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

  • Biochemical families: carbohydrates
    • alcohols
    • glycoproteins
    • glycosides
  • lipids
    • eicosanoids
    • fatty acids / intermediates
    • phospholipids
    • sphingolipids
    • steroids
  • nucleic acids
    • constituents / intermediates
  • proteins
    • Amino acids / intermediates
  • tetrapyrroles / intermediates
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