Enterobacteria phage P2

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Bacteriophage P2 is a temperate phage that infects E. coli. It is a tailed virus with a contractile sheath and is thus classified in the family Myoviridae and the order Caudovirales. This class of viruses includes many P2-like phages as well as the satellite phage P4.[1]

Enterobacteria phage P2

Virion structure

Phage P2 has a double stranded DNA genome packaged in an icosahedral capsid with a diameter of 60 nanometers that is connected to a 135 nanometer long tail. Presence of phage P4 can cause P2 to form smaller capsids.[2] The tail ends in a baseplate which is the control hub for phage infectivity. The baseplate includes 6 tail fibers which initially bind to receptors on the bacterial cell wall and a tail spike protein that subsequently binds irreversibly to other receptors on the cell wall.

References

  1. ↑ Bowden, DW; Modrich, P (Jun 10, 1985). "In vitro maturation of circular bacteriophage P2 DNA. Purification of ter components and characterization of the reaction.". The Journal of Biological Chemistry 260 (11): 6999–7007. PMID 2987239. 
  2. ↑ Dearborn, AD; Laurinmaki, P, Chandramouli, P, Rodenburg, CM, Wang, S, Butcher, SJ, Dokland, T (Apr 9, 2012). "Structure and size determination of bacteriophage P2 and P4 procapsids: Function of size responsiveness mutations.". Journal of structural biology 178 (3): 215–24. doi:10.1016/j.jsb.2012.04.002. PMID 22508104. 


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