Enprofylline

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Enprofylline

Systematic (IUPAC) name
3-propyl-7H-purine-2,6-dione
Clinical data
Legal status	?
Identifiers
CAS number	41078-02-8^Y
ATC code	?
PubChem	CID 1676
DrugBank	DB00824
ChemSpider	1613^Y
UNII	DT7DT5E518^N
ChEBI	CHEBI:126237^N
ChEMBL	CHEMBL279898^N
Chemical data
Formula	C₈H₁₀N₄O₂
Mol. mass	194.190 g/mol
SMILES O=C2N(c1ncnc1C(=O)N2)CCC
InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14)^Y Key:SIQPXVQCUCHWDI-UHFFFAOYSA-N^Y
N (what is this?) (verify)

Enprofylline (3-Propylxanthine) is a xanthine derivative used in the treatment of asthma, which acts as a bronchodilator. It acts primarily as a competitive nonselective phosphodiesterase inhibitor with relatively little activity as a nonselective adenosine receptor antagonist.^[1]^[2]

References

↑ Lunell E, Svedmyr N, Andersson KE, Persson CG (1982). "Effects of enprofylline, a xanthine lacking adenosine receptor antagonism, in patients with chronic obstructive lung disease". European Journal of Clinical Pharmacology 22 (5): 395–402. PMID 6288396.
↑ Laursen LC (December 1987). "Anti asthmatic effects and pharmacokinetics of enprofylline--a new xanthine derivate". Danish Medical Bulletin 34 (6): 289–97. PMID 3325233.

Drugs for obstructive airway diseases: asthma/COPD (R03)

Adrenergics, inhalants

Short acting β₂-agonists	Bitolterol Carbuterol Fenoterol Pirbuterol Procaterol Reproterol Rimiterol Salbutamol^#/Levosalbutamol Terbutaline Tulobuterol

Long acting β₂-agonists (LABA)	Arformoterol Bambuterol Clenbuterol Formoterol Salmeterol Ultra LABA: Indacaterol, Olodaterol, Vilanterol

other	Epinephrine^# Hexoprenaline Isoprenaline (Isoproterenol) Orciprenaline (Metaproterenol)

Eicosanoid inhibition

Leukotriene antagonists	Montelukast Pranlukast Zafirlukast

Lipoxygenase inhibitor	Zileuton

Thromboxane receptor antagonists	Ramatroban Seratrodast

Non-xanthine PDE4 inhibitors	Ibudilast Roflumilast

Others/unknown

Combination products

anat (n, x, l, c)/phys/devp

noco (c, p)/cong/tumr, sysi/epon, injr

proc, drug (R1/2/3/5/6/7)

Agonists	2-(1-Hexynyl)-N-methyladenosine 2-Cl-IB-MECA 2'-MeCCPA 5'-N-ethylcarboxamidoadenosine ATL-146e BAY 60–6583 CCPA CGS-21680 CP-532,903 GR 79236 LUF-5835 LUF-5845 N⁶-Cyclopentyladenosine Regadenoson SDZ WAG 994 UK-432,097

Antagonists	8-Phenyl-1,3-dipropylxanthine Acefylline Aminophylline Bamifylline Caffeine CGS-15943 8-Chlorotheophylline CPX CVT-6883 Dimethazan DPCPX Fenethylline Istradefylline KF-26777 MRE3008F20 MRS-1220 MRS-1334 MRS-1706 MRS-1754 MRS-3777 Paraxanthine Pentoxifylline Preladenant Propentofylline PSB-10 PSB-11 PSB 36 PSB-603 PSB-788 PSB-1115 Rolofylline SCH-442,416 SCH-58261 Theobromine Theophylline VUF-5574 ZM-241,385

ENT inhibitors	Dilazep Dipyridamole Hexobendine Pentoxifylline Propentofylline Barbiturates Ethanol Benzodiazepines

VNT inhibitors

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