Enkephalinase inhibitor
From Wikipedia, the free encyclopedia
Thiorphan, a potent enkephalinase inhibitor and the active metabolite of the prodrug racecadotril, a medication used medicinally as an antidiarrheal.
An enkephalinase inhibitor is a type of enzyme inhibitor which inhibits one or more members of the enkephalinase class of enzymes that break down the endogenous enkephalin opioid peptides.
Some examples of enkephalinase inhibitors include bestatin, BL-2401, kelatorphan, D-phenylalanine, racecadotril, RB-101, RB-120, RB-3007, thiorphan, tynorphin, and ubenimex, as well as the endogenous compounds opiorphin and spinorphin.[1]
Analgesic, anticraving, antidepressant, anxiolytic, and antidiarrheal effects are common properties of enkephalinase inhibitors.[1]
See also
References
- ↑ 1.0 1.1 Thanawala V, Kadam VJ, Ghosh R (October 2008). "Enkephalinase inhibitors: potential agents for the management of pain". Current Drug Targets 9 (10): 887–94. doi:10.2174/138945008785909356. PMID 18855623.
| |||||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||
This article is issued from Wikipedia. The text is available under the Creative Commons Attribution/Share Alike; additional terms may apply for the media files.