Endothelin 1

Endothelin 1
Rendering of 1EDN
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1EDN, 1EDP, 1T7H, 1V6R
Identifiers
Symbols	EDN1; ET1; HDLCQ7; PPET1
External IDs	OMIM: 131240 MGI: 95283 HomoloGene: 1476 GeneCards: EDN1 Gene
Gene Ontology Molecular function • cytokine activity • hormone activity • endothelin A receptor binding • endothelin B receptor binding Cellular component • extracellular region • extracellular space • cytoplasm Biological process • negative regulation of transcription from RNA polymerase II promoter • prostaglandin biosynthetic process • patterning of blood vessels • response to hypoxia • in utero embryonic development • histamine secretion • regulation of systemic arterial blood pressure by endothelin • regulation of pH • cell surface receptor signaling pathway • G-protein coupled receptor signaling pathway • elevation of cytosolic calcium ion concentration • protein kinase C-activating G-protein coupled receptor signaling pathway • intracellular protein kinase cascade • cell-cell signaling • heart development • respiratory gaseous exchange • body fluid secretion • positive regulation of cell proliferation • dorsal/ventral pattern formation • multicellular organismal aging • positive regulation of heart rate • positive regulation of endothelial cell migration • positive regulation of cardiac muscle hypertrophy • positive regulation of receptor biosynthetic process • neural crest cell development • phosphatidylinositol 3-kinase cascade • artery smooth muscle contraction • vein smooth muscle contraction • glucose transport • cell growth • regulation of vasoconstriction • sensory perception of pain • calcium-mediated signaling • peptide hormone secretion • nitric oxide transport • negative regulation of blood coagulation • positive regulation of cell migration • neutrophil chemotaxis • negative regulation of cAMP biosynthetic process • phospholipase D-activating G-protein coupled receptor signaling pathway • negative regulation of cellular protein metabolic process • response to lipopolysaccharide • response to testosterone stimulus • negative regulation of smooth muscle cell apoptotic process • response to nicotine • positive regulation of urine volume • positive regulation of renal sodium excretion • epithelial fluid transport • vasoconstriction • protein kinase C deactivation • middle ear morphogenesis • positive regulation of odontogenesis • superoxide anion generation • rhythmic excitation • response to amino acid stimulus • positive regulation of MAP kinase activity • positive regulation of JUN kinase activity • leukocyte activation • positive regulation of nitric oxide biosynthetic process • positive regulation of cell size • positive regulation of mitosis • positive regulation of smooth muscle contraction • positive regulation of hormone secretion • negative regulation of hormone secretion • inositol phosphate-mediated signaling • positive regulation of smooth muscle cell proliferation • cartilage development • elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway • negative regulation of nitric-oxide synthase biosynthetic process • membrane depolarization • regulation of sensory perception of pain • maternal process involved in parturition • positive regulation of sarcomere organization • positive regulation of prostaglandin-endoperoxide synthase activity • positive regulation of chemokine-mediated signaling pathway • cellular response to interleukin-1 • cellular response to tumor necrosis factor • positive regulation of neutrophil chemotaxis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1906	13614
Ensembl	ENSG00000078401	ENSMUSG00000021367
UniProt	P05305	P22387
RefSeq (mRNA)	NM_001168319	NM_010104
RefSeq (protein)	NP_001161791	NP_034234
Location (UCSC)	Chr 6: 12.29 – 12.3 Mb	Chr 13: 42.3 – 42.31 Mb
PubMed search
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Endothelin 1, also known as preproendothelin-1 (PPET1), is a protein that in humans is encoded by the EDN1 gene. The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 is one of three isoforms of human endothelin (ET-1).

Preproendothelin is precursor of the peptide ET-1. Endothelial cells convert preproendothelin to proendothelin and subsequently to mature endothelin, which the cells release.^[1]

Endothelin-1 receptor antagonists (Bosentan) are used in the treatment of pulmonary hypertension. Inhibition of these receptors prevents pulmonary vasculature constriction, thus decreasing pulmonary vascular resistance.

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.