Embryonic hemoglobin
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Embryonic hemoglobin is a tetramer produced in the blood islands in the embryonic yolk sac during the mesoblastic stage (first week of pregnancy until the end of the pregnancy). The protein is commonly referred to as Hemoglobin ε or HbE.
Chromosomal abnormalities can lead to a delay in switching from embryonic hemoglobin.[1]
Subtypes include Gower 1, Gower 2, and Portland 2.[2]
References
- ↑ Al-Mufti R, Hambley H, Farzaneh F, Nicolaides KH (July 2000). "Fetal and embryonic hemoglobins in erythroblasts of chromosomally normal and abnormal fetuses at 10-40 weeks of gestation". Haematologica 85 (7): 690–3. PMID 10897119.
- ↑ He Z, Russell JE (February 2001). "Expression, purification, and characterization of human hemoglobins Gower-1 (zeta(2)epsilon(2)), Gower-2 (alpha(2)epsilon(2)), and Portland-2 (zeta(2)beta(2)) assembled in complex transgenic-knockout mice". Blood 97 (4): 1099–105. doi:10.1182/blood.V97.4.1099. PMID 11159543.
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