Elfazepam

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Elfazepam

Systematic (IUPAC) name
7-Chloro-1-(2-ethylsulfonylethyl)-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one
Clinical data
Legal status	?
Identifiers
CAS number	52042-01-0^Y
ATC code	None
PubChem	CID 65445
ChemSpider	58907^Y
UNII	RM53R5R2BL^Y
Chemical data
Formula	C₁₉H₁₈Cl F N₂O₃S
Mol. mass	408.87
SMILES O=S(CC)(CCN1C(CN=C(C2=CC=CC=C2F)C3=C1C=CC(Cl)=C3)=O)=O
InChI InChI=1S/C19H18ClFN2O3S/c1-2-27(25,26)10-9-23-17-8-7-13(20)11-15(17)19(22-12-18(23)24)14-5-3-4-6-16(14)21/h3-8,11H,2,9-10,12H2,1H3^Y Key:BSPSXMXQKZZNFP-UHFFFAOYSA-N^Y
Y (what is this?) (verify)

Elfazepam^[1] is a drug which is a benzodiazepine derivative.^[2] Presumably it has sedative and anxiolytic actions like those of other benzodiazepines.

It has appetite stimulating properties in animals.^[3]^[4] The mechanism for increasing feed intake is not clear and has been subject of investigation.^[5] It has been found that elfazepam suppresses gastric acid secretion.^[6]

References

↑ U.S. Patent 4,010,154
↑ Psychotropics.dk
↑ Baile, CA.; McLaughlin, CL. (Nov 1979). "A review of the behavioral and physiological responses to elfazepam, a chemical feed intake stimulant.". J Anim Sci 49 (5): 1371–95. PMID 396294.
↑ Baile, CA.; Naylor, J.; McLaughlin, CL.; Catanzaro, CA. (Aug 1981). "Endotoxin-elicited fever and anorexia and elfazepam-stimulated feeding in sheep.". Physiol Behav 27 (2): 271–7. PMID 7029576.
↑ Keim, DA.; Baile, CA.; Bolton, JR.; Wangsness, PJ.; Della Fera, MA. (Jan 1979). "Abomasal function following injections of elfazepam and 9-aza-cannabinol.". Pharmacol Biochem Behav 10 (1): 63–70. PMID 35793.
↑ Van Den Broek, GW.; Robertson, J.; Keim, DA.; Baile, CA. (Jul 1979). "Feeding and depression of abomasal secretion in sheep elicited by elfazepam and 9-aza-cannabinol.". Pharmacol Biochem Behav 11 (1): 51–6. PMID 493298.

v t e Benzodiazepine derivatives

1,4-Benzodiazepines	Bromazepam Camazepam Carburazepam Chlordiazepoxide Cinazepam Cinolazepam Clonazepam Clorazepate Cyprazepam Delorazepam Demoxepam Devazepide * Diazepam Diclazepam Doxefazepam Elfazepam Ethyl carfluzepate Ethyl dirazepate Ethyl loflazepate Flubromazepam Fletazepam Fludiazepam Flunitrazepam Flurazepam Flutemazepam Flutoprazepam Fosazepam Gidazepam Halazepam Iclazepam Ketazolam Lorazepam Lormetazepam Lufuradom * Meclonazepam Medazepam Menitrazepam Metaclazepam Motrazepam Nimetazepam Nitrazepam Nitrazepate Nordazepam Nortetrazepam Oxazepam Phenazepam Pinazepam Pivoxazepam Prazepam Proflazepam Quazepam QH-II-66 Reclazepam RO4491533 * Ro5-2904 Ro5-4864 * Sulazepam Temazepam Tetrazepam Tifluadom * Tolufazepam Tuclazepam Uldazepam

1,5-Benzodiazepines	Arfendazam Clobazam CP-1414S Lofendazam Triflubazam

2,3-Benzodiazepines *	Girisopam GYKI-52466 GYKI-52895 Nerisopam Talampanel Tofisopam

Triazolobenzodiazepines	Adinazolam Alprazolam Estazolam Flubromazolam Pyrazolam Triazolam

Imidazobenzodiazepines	Bretazenil Climazolam FG-8205 Flumazenil Imidazenil Iomazenil (¹²³I) L-655,708 Loprazolam Midazolam PWZ-029 Remimazolam Ro15-4513 Ro48-6791 Ro48-8684 Ro4938581 Sarmazenil SH-053-R-CH3-2′F

Oxazolobenzodiazepines	Cloxazolam Flutazolam Haloxazolam Mexazolam Oxazolam

Thienodiazepines	Bentazepam Brotizolam Ciclotizolam Clotiazepam Etizolam JQ1 * Olanzapine *

Pyridodiazepines	Lopirazepam Zapizolam

Pyrazolodiazepines	Razobazam * Ripazepam Zolazepam Zomebazam Zometapine *

Pyrrolodiazepines	Premazepam

Tetrahydroisoquinobenzodiazepines	Clazolam

Benzodiazepine prodrugs	Avizafone Rilmazafone

* atypical activity profile (not GABA_A receptor ligands)

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