EPN1

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Epsin 1

PDB rendering based on 1edu.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolEPN1
External IDsOMIM: 607262 MGI: 1333763 HomoloGene: 32172 GeneCards: EPN1 Gene
Orthologs
SpeciesHumanMouse
Entrez2992413854
EnsemblENSG00000063245ENSMUSG00000035203
UniProtQ9Y6I3Q80VP1
RefSeq (mRNA)NM_001130071NM_001252454
RefSeq (protein)NP_001123543NP_001239383
Location (UCSC)Chr 19:
56.19 – 56.22 Mb
Chr 7:
5.08 – 5.1 Mb
PubMed search

Epsin-1 is a protein that in humans is encoded by the EPN1 gene.[1][2][3]

EPN1 is an endocytic accessory protein that interacts with EPS15 (MIM 600051), the alpha subunit of the clathrin adaptor AP2 (AP2A1; MIM 601026), and clathrin (see MIM 118960), as well as with other accessory proteins for the endocytosis of clathrin-coated vesicles.[supplied by OMIM][3]

Interactions

EPN1 has been shown to interact with REPS2,[2] AP2A2[1] and EPS15.[1]

References

  1. 1.0 1.1 1.2 Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P (Sep 1998). "Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis". Nature 394 (6695): 793–7. doi:10.1038/29555. PMID 9723620. 
  2. 2.0 2.1 Morinaka K, Koyama S, Nakashima S, Hinoi T, Okawa K, Iwamatsu A, Kikuchi A (Dec 1999). "Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis". Oncogene 18 (43): 5915–22. doi:10.1038/sj.onc.1202974. PMID 10557078. 
  3. 3.0 3.1 "Entrez Gene: EPN1 epsin 1". 

Further reading

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