EMR1

From Wikipedia, the free encyclopedia

Egf-like module containing, mucin-like, hormone receptor-like 1

Identifiers

EMR1; TM7LN3

External IDs

OMIM: 600493 MGI: 106912 HomoloGene: 1493 IUPHAR: EMR1 GeneCards: EMR1 Gene

Gene Ontology
Molecular function	• G-protein coupled receptor activity • calcium ion binding
Cellular component	• integral to plasma membrane • external side of plasma membrane
Biological process	• cell adhesion • G-protein coupled receptor signaling pathway • neuropeptide signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
6.89 – 6.94 Mb

Chr 17:
57.36 – 57.48 Mb

PubMed search

EGF-like module-containing mucin-like hormone receptor-like 1 is a protein that in humans is encoded by the EMR1 gene.^[1]^[2]^[3] The mouse homologue is known as F4/80.^[4]

Function

This gene encodes a protein that is a member of the adhesion-GPCR family. ^[5] Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 region via membrane proximal GAIN domain. In the case of EMR1 these domains are Epidermal Growth Factor (EGF-like) domains.

Emr1 is a transmembrane protein present on the cell-surface of human macrophages, which are derived from the myeloid lineage. It has an approximate mass of 125 kDa, and is associated with mature macrophages.

References

↑ Baud V, Chissoe SL, Viegas-Pequignot E, Diriong S, N'Guyen VC, Roe BA, Lipinski M (Aug 1995). "EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments". Genomics 26 (2): 334–44. doi:10.1016/0888-7543(95)80218-B. PMID 7601460.
↑ McKnight AJ, Gordon S (Mar 1998). "The EGF-TM7 family: unusual structures at the leukocyte surface". J Leukoc Biol 63 (3): 271–80. PMID 9500513.
↑ "Entrez Gene: EMR1 egf-like module containing, mucin-like, hormone receptor-like 1".
↑ Leenen PJ, de Bruijn MF, Voerman JS, Campbell PA, van Ewijk W (September 1994). "Markers of mouse macrophage development detected by monoclonal antibodies". J. Immunol. Methods 174 (1-2): 5–19. PMID 8083537.
↑ Yona, Stacey (2011). Adhesion-GPCRs. Springer. pp. 1–200. ISBN 978-1-4419-7912-4.

McKnight AJ, Macfarlane AJ, Seldin MF, Gordon S (1998). "Chromosome mapping of the Emr1 gene". Mamm. Genome 8 (12): 946. doi:10.1007/s003359900633. PMID 9383301.
Carver EA, Hamann J, Olsen AS, Stubbs L (2000). "Physical mapping of EMR1 and CD97 in human Chromosome 19 and assignment of Cd97 to mouse Chromosome 8 suggest an ancient genomic duplication". Mamm. Genome 10 (10): 1039–40. doi:10.1007/s003359901157. PMID 10501980.
Lin HH, Stacey M, Hamann J, et al. (2000). "Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97". Genomics 67 (2): 188–200. doi:10.1006/geno.2000.6238. PMID 10903844.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

Cell surface receptor: G protein-coupled receptors

Class A:
Rhodopsin like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3

Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)

Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)

Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine (D1 D2 D3 D4 D5) Histamine (H1 H2 H3 H4) Melatonin (1A 1B 1C) TAAR (1 2 3 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 (1 2) FPRL1 OXE Prostaglandin (DP (1 2), EP (1 2 3 4), FP) Prostacyclin Thromboxane

Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Lactate Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Niacin (1 2) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide	B/W (1 2) FF (1 2) S Y (1 2 4 5) Neuromedin (B U (1 2)) Neurotensin (1 2)

Other	Anaphylatoxin (C3a C5a) Angiotensin (1 2) Apelin Bombesin (BRS3 GRPR NMBR) Bradykinin (B1 B2) Chemokine Cholecystokinin (A B) Endothelin (A B) Formyl peptide (1 2 3) FSH Galanin (1 2 3) GHB receptor Gonadotropin-releasing hormone (1 2) Ghrelin Kisspeptin Luteinizing hormone/choriogonadotropin MAS (1 1L D E F G X1 X2 X3 X4) Melanocortin (1 2 3 4 5) MCHR (1 2) Motilin Opioid (Delta Kappa Mu Nociceptin & Zeta, but not Sigma) Orexin (1 2) Oxytocin Prokineticin (1 2) Prolactin-releasing peptide Relaxin (1 2 3 4) Somatostatin (1 2 3 4 5) Tachykinin (1 2 3) Thyrotropin Thyrotropin-releasing hormone Urotensin-II Vasopressin (1A 1B 2)

Miscellaneous

Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 77 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)

Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B: Secretin like

Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)

Other	Brain-specific angiogenesis inhibitor (1 2 3) Cadherin (1 2 3) Calcitonin CALCRL CD97 Corticotropin-releasing hormone (1 2) EMR (1 2 3) Glucagon (GR GIPR GLP1R GLP2R) Growth hormone releasing hormone PACAPR1 GPR Latrophilin (1 2 3 ELTD1) Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C: Metabotropic
glutamate / pheromone

Taste	TAS1R (1 2 3) TAS2R (1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60)

Other	Calcium-sensing receptor GABA B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F:
Frizzled / Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)

Smoothened	Smoothened

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

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EMR1

Function

See also

References

Further reading