EIF4A1

From Wikipedia, the free encyclopedia

Eukaryotic translation initiation factor 4A1

PDB rendering based on 2g9n.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2G9N, 2ZU6, 3EIQ

Identifiers

Symbols

EIF4A1; DDX2A; EIF-4A; EIF4A; eIF-4A-I; eIF4A-I

External IDs

OMIM: 602641 MGI: 95303 HomoloGene: 103998 GeneCards: EIF4A1 Gene

EC number

3.6.4.13

Gene Ontology
Molecular function	• RNA cap binding • mRNA binding • translation initiation factor activity • helicase activity • protein binding • ATP binding • ATP-dependent helicase activity • translation factor activity, nucleic acid binding
Cellular component	• cytosol • eukaryotic translation initiation factor 4F complex
Biological process	• nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • nuclear-transcribed mRNA poly(A) tail shortening • translation • translational initiation • gene expression • RNA metabolic process • mRNA metabolic process • virus-host interaction • cytokine-mediated signaling pathway • cellular protein metabolic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
7.48 – 7.48 Mb

Chr 11:
69.67 – 69.67 Mb

PubMed search

Eukaryotic initiation factor 4A-I is a protein that in humans is encoded by the EIF4A1 gene.^[1]^[2]^[3]

Interactions

EIF4A1 has been shown to interact with EIF4E^[4]^[5] and Eukaryotic translation initiation factor 4 gamma.^[4]^[5]^[6]

References

↑ Kim NS, Kato T, Abe N, Kato S (Jun 1993). "Nucleotide sequence of human cDNA encoding eukaryotic initiation factor 4AI". Nucleic Acids Res 21 (8): 2012. doi:10.1093/nar/21.8.2012. PMC 309447. PMID 8493113.
↑ Jones E, Quinn CM, See CG, Montgomery DS, Ford MJ, Kolble K, Gordon S, Greaves DR (Dec 1998). "The linked human elongation initiation factor 4A1 (EIF4A1) and CD68 genes map to chromosome 17p13". Genomics 53 (2): 248–50. doi:10.1006/geno.1998.5515. PMID 9790779.
↑ "Entrez Gene: EIF4A1 eukaryotic translation initiation factor 4A, isoform 1".
↑ 4.0 4.1 Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. Cite uses deprecated parameters (help)
↑ 5.0 5.1 Connolly, Eileen; Braunstein Steve, Formenti Silvia, Schneider Robert J (May 2006). "Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells". Mol. Cell. Biol. (United States) 26 (10): 3955–65. doi:10.1128/MCB.26.10.3955-3965.2006. ISSN 0270-7306. PMC 1489005. PMID 16648488. Cite uses deprecated parameters (help)
↑ Harris, Thurl E; Chi An, Shabanowitz Jeffrey, Hunt Donald F, Rhoads Robert E, Lawrence John C (Apr 2006). "mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin". EMBO J. (England) 25 (8): 1659–68. doi:10.1038/sj.emboj.7601047. ISSN 0261-4189. PMC 1440840. PMID 16541103. Cite uses deprecated parameters (help)

Reddy NS, Roth WW, Bragg PW, Wahba AJ (1989). "Isolation and mapping of a gene for protein synthesis initiation factor 4A and its expression during differentiation of murine erythroleukemia cells.". Gene 70 (2): 231–43. doi:10.1016/0378-1119(88)90195-3. PMID 3215517.
Kukimoto I, Watanabe S, Taniguchi K, et al. (1997). "Characterization of the cloned promoter of the human initiation factor 4AI gene.". Biochem. Biophys. Res. Commun. 233 (3): 844–7. doi:10.1006/bbrc.1997.6555. PMID 9168945.
Imataka H, Sonenberg N (1997). "Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A.". Mol. Cell. Biol. 17 (12): 6940–7. PMC 232551. PMID 9372926.
Gradi A, Imataka H, Svitkin YV, et al. (1998). "A novel functional human eukaryotic translation initiation factor 4G.". Mol. Cell. Biol. 18 (1): 334–42. PMC 121501. PMID 9418880.
Craig AW, Haghighat A, Yu AT, Sonenberg N (1998). "Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation.". Nature 392 (6675): 520–3. doi:10.1038/33198. PMID 9548260.
Henis-Korenblit S, Strumpf NL, Goldstaub D, Kimchi A (2000). "A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation.". Mol. Cell. Biol. 20 (2): 496–506. doi:10.1128/MCB.20.2.496-506.2000. PMC 85113. PMID 10611228.
Quinn CM, Wiles AP, El-Shanawany T, et al. (2000). "The human eukaryotic initiation factor 4AI gene (EIF4A1) contains multiple regulatory elements that direct high-level reporter gene expression in mammalian cell lines.". Genomics 62 (3): 468–76. doi:10.1006/geno.1999.6031. PMID 10644445.
Cuesta R, Xi Q, Schneider RJ (2000). "Adenovirus-specific translation by displacement of kinase Mnk1 from cap-initiation complex eIF4F.". EMBO J. 19 (13): 3465–74. doi:10.1093/emboj/19.13.3465. PMC 313943. PMID 10880459.
Mendell JT, Medghalchi SM, Lake RG, et al. (2000). "Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes.". Mol. Cell. Biol. 20 (23): 8944–57. doi:10.1128/MCB.20.23.8944-8957.2000. PMC 86549. PMID 11073994.
Li W, Belsham GJ, Proud CG (2001). "Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo.". J. Biol. Chem. 276 (31): 29111–5. doi:10.1074/jbc.C100284200. PMID 11408474.
Du MX, Johnson RB, Sun XL, et al. (2002). "Comparative characterization of two DEAD-box RNA helicases in superfamily II: human translation-initiation factor 4A and hepatitis C virus non-structural protein 3 (NS3) helicase.". Biochem. J. 363 (Pt 1): 147–55. doi:10.1042/0264-6021:3630147. PMC 1222461. PMID 11903057.
Bohnsack MT, Regener K, Schwappach B, et al. (2003). "Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.". EMBO J. 21 (22): 6205–15. doi:10.1093/emboj/cdf613. PMC 137205. PMID 12426392.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yang HS, Cho MH, Zakowicz H, et al. (2004). "A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A.". Mol. Cell. Biol. 24 (9): 3894–906. doi:10.1128/MCB.24.9.3894-3906.2004. PMC 387765. PMID 15082783.
Mingot JM, Bohnsack MT, Jäkle U, Görlich D (2005). "Exportin 7 defines a novel general nuclear export pathway.". EMBO J. 23 (16): 3227–36. doi:10.1038/sj.emboj.7600338. PMC 514512. PMID 15282546.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hinton TM, Coldwell MJ, Carpenter GA, et al. (2007). "Functional analysis of individual binding activities of the scaffold protein eIF4G.". J. Biol. Chem. 282 (3): 1695–708. doi:10.1074/jbc.M602780200. PMID 17130132.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

PDB gallery

2g9n: Structure of the DEAD domain of Human eukaryotic initiation factor 4A, eIF4A

This article is issued from Wikipedia. The text is available under the Creative Commons Attribution/Share Alike; additional terms may apply for the media files.

EIF4A1

Interactions

References

Further reading