EIF2C2

From Wikipedia, the free encyclopedia
Argonaute RISC catalytic component 2

Rendering based on PDB 3LUC.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsAGO2; EIF2C2; Q10
External IDsOMIM: 606229 MGI: 2446632 HomoloGene: 81825 GeneCards: AGO2 Gene
Orthologs
SpeciesHumanMouse
Entrez27161239528
EnsemblENSG00000123908ENSMUSG00000036698
UniProtQ9UKV8Q8CJG0
RefSeq (mRNA)NM_001164623NM_153178
RefSeq (protein)NP_001158095NP_694818
Location (UCSC)Chr 8:
141.54 – 141.65 Mb
Chr 15:
73.1 – 73.18 Mb
PubMed search

Protein argonaute-2 is a protein that in humans is encoded by the EIF2C2 gene.[1][2][3]

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with Dicer1 and play a role in short-interfering-RNA-mediated gene silencing.[3]

Interactions

EIF2C2 has been shown to interact with

References

  1. Koesters R, Adams V, Betts D, Moos R, Schmid M, Siermann A, Hassam S, Weitz S, Lichter P, Heitz PU, von Knebel Doeberitz M, Briner J (Dec 1999). "Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression". Genomics 61 (2): 210–8. doi:10.1006/geno.1999.5951. PMID 10534406. 
  2. Sasaki T, Shiohama A, Minoshima S, Shimizu N (Aug 2003). "Identification of eight members of the Argonaute family in the human genome small star, filled". Genomics 82 (3): 323–30. doi:10.1016/S0888-7543(03)00129-0. PMID 12906857. 
  3. 3.0 3.1 "Entrez Gene: EIF2C2 eukaryotic translation initiation factor 2C, 2". 
  4. Nelson PT, Hatzigeorgiou AG, Mourelatos Z (March 2004). "miRNP:mRNA association in polyribosomes in a human neuronal cell line". RNA 10 (3): 387–94. doi:10.1261/rna.5181104. PMC 1370934. PMID 14970384. 
  5. 5.0 5.1 Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G (March 2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. 16 (6): 720–8. doi:10.1101/gad.974702. PMC 155365. PMID 11914277. 
  6. Doi N, Zenno S, Ueda R, Ohki-Hamazaki H, Ui-Tei K, Saigo K (January 2003). "Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors". Curr. Biol. 13 (1): 41–6. doi:10.1016/S0960-9822(02)01394-5. PMID 12526743. 
  7. Jin P, Zarnescu DC, Ceman S, Nakamoto M, Mowrey J, Jongens TA, Nelson DL, Moses K, Warren ST (February 2004). "Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway". Nat. Neurosci. 7 (2): 113–7. doi:10.1038/nn1174. PMID 14703574. 
  8. Till S, Lejeune E, Thermann R, Bortfeld M, Hothorn M, Enderle D, Heinrich C, Hentze MW, Ladurner AG (October 2007). "A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain". Nat. Struct. Mol. Biol. 14 (10): 897–903. doi:10.1038/nsmb1302. PMID 17891150. 

Further reading

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