EIF2AK4
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| Eukaryotic translation initiation factor 2 alpha kinase 4 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | EIF2AK4; GCN2 | ||||||||||||
| External IDs | OMIM: 609280 MGI: 1353427 HomoloGene: 40891 ChEMBL: 5358 GeneCards: EIF2AK4 Gene | ||||||||||||
| EC number | 2.7.11.1 | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 440275 | 27103 | |||||||||||
| Ensembl | ENSG00000128829 | ENSMUSG00000005102 | |||||||||||
| UniProt | Q9P2K8 | Q9QZ05 | |||||||||||
| RefSeq (mRNA) | NM_001013703 | NM_001177806 | |||||||||||
| RefSeq (protein) | NP_001013725 | NP_001171277 | |||||||||||
| Location (UCSC) | Chr 15: 40.23 – 40.33 Mb | Chr 2: 118.39 – 118.48 Mb | |||||||||||
| PubMed search | |||||||||||||
Eukaryotic translation initiation factor 2-alpha kinase 4 is an enzyme that in humans is encoded by the EIF2AK4 gene.[1][2]
EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999).[supplied by OMIM][2]
See also
References
- ↑ Berlanga JJ, Santoyo J, De Haro C (Nov 1999). "Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase". Eur J Biochem 265 (2): 754–62. doi:10.1046/j.1432-1327.1999.00780.x. PMID 10504407.
- ↑ 2.0 2.1 "Entrez Gene: EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4".
Further reading
- Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Clark AG, Glanowski S, Nielsen R, et al. (2003). "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios.". Science 302 (5652): 1960–3. doi:10.1126/science.1088821. PMID 14671302.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.". Mol. Cell Proteomics 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.
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