EHMT2

From Wikipedia, the free encyclopedia

Euchromatic histone-lysine N-methyltransferase 2

PDB rendering based on 2o8j.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2O8J, 3DM1, 3K5K, 3RJW

Identifiers

Symbols

EHMT2; BAT8; C6orf30; G9A; GAT8; KMT1C; NG36

External IDs

OMIM: 604599 MGI: 2148922 HomoloGene: 48460 ChEMBL: 6032 GeneCards: EHMT2 Gene

EC number

2.1.1.43

Gene Ontology
Molecular function	• p53 binding • protein binding • zinc ion binding • protein-lysine N-methyltransferase activity • histone-lysine N-methyltransferase activity • histone methyltransferase activity (H3-K9 specific) • histone methyltransferase activity (H3-K27 specific)
Cellular component	• nucleus • chromosome
Biological process	• negative regulation of transcription from RNA polymerase II promoter • pachytene • regulation of DNA replication • DNA methylation • synaptonemal complex assembly • spermatid development • fertilization • DNA methylation on cytosine within a CG sequence • histone methylation • peptidyl-lysine dimethylation • organ growth
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
31.85 – 31.87 Mb

Chr 17:
34.9 – 34.91 Mb

PubMed search

Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 is a histone methyltransferase that in humans is encoded by the EHMT2 gene.^[1]^[2]^[3]

A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. This gene is found near this cluster; it was mapped near the gene for C2 within a 120-kb region that included a HSP70 gene pair. These genes are all within the human major histocompatibility complex class III region. This gene was thought to be two different genes, NG36 and G9a, adjacent to each other but a recent publication shows that there is only a single gene. The protein encoded by this gene is thought to be involved in intracellular protein-protein interaction. There are three alternatively spliced transcript variants of this gene but only two are fully described.^[3]

Interactions

EHMT2 has been shown to interact with KIAA0515.^[4]

References

↑ Milner CM, Campbell RD (April 1993). "The G9a gene in the human major histocompatibility complex encodes a novel protein containing ankyrin-like repeats". Biochem J. 290 ( Pt 3) (Pt 3): 811–8. PMC 1132354. PMID 8457211.
↑ Tachibana M, Sugimoto K, Fukushima T, Shinkai Y (July 2001). "Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3". J Biol Chem 276 (27): 25309–17. doi:10.1074/jbc.M101914200. PMID 11316813.
↑ 3.0 3.1 "Entrez Gene: EHMT2 euchromatic histone-lysine N-methyltransferase 2".
↑ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. Cite uses deprecated parameters (help)

Spies T, Bresnahan M, Strominger JL (1989). "Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B". Proc. Natl. Acad. Sci. U.S.A. 86 (22): 8955–8. doi:10.1073/pnas.86.22.8955. PMC 298409. PMID 2813433.
Brown SE, Campbell RD, Sanderson CM (2002). "Novel NG36/G9a gene products encoded within the human and mouse MHC class III regions". Mamm. Genome 12 (12): 916–24. doi:10.1007/s00335-001-3029-3. PMID 11707778.
Ogawa H, Ishiguro K, Gaubatz S et al. (2002). "A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells". Science 296 (5570): 1132–6. doi:10.1126/science.1069861. PMID 12004135.
Tachibana M, Sugimoto K, Nozaki M et al. (2002). "G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis". Genes Dev. 16 (14): 1779–91. doi:10.1101/gad.989402. PMC 186403. PMID 12130538.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Shi Y, Sawada J, Sui G et al. (2003). "Coordinated histone modifications mediated by a CtBP co-repressor complex". Nature 422 (6933): 735–8. doi:10.1038/nature01550. PMID 12700765.
Xie T, Rowen L, Aguado B et al. (2004). "Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Roopra A, Qazi R, Schoenike B et al. (2005). "Localized domains of G9a-mediated histone methylation are required for silencing of neuronal genes". Mol. Cell 14 (6): 727–38. doi:10.1016/j.molcel.2004.05.026. PMID 15200951.
Nishio H, Walsh MJ (2004). "CCAAT displacement protein/cut homolog recruits G9a histone lysine methyltransferase to repress transcription". Proc. Natl. Acad. Sci. U.S.A. 101 (31): 11257–62. doi:10.1073/pnas.0401343101. PMC 509191. PMID 15269344.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Collins RE, Tachibana M, Tamaru H et al. (2005). "In Vitro and in Vivo Analyses of a Phe/Tyr Switch Controlling Product Specificity of Histone Lysine Methyltransferases". J. Biol. Chem. 280 (7): 5563–70. doi:10.1074/jbc.M410483200. PMC 2696276. PMID 15590646.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Duan Z, Zarebski A, Montoya-Durango D et al. (2005). "Gfi1 Coordinates Epigenetic Repression of p21Cip/WAF1 by Recruitment of Histone Lysine Methyltransferase G9a and Histone Deacetylase 1". Mol. Cell. Biol. 25 (23): 10338–51. doi:10.1128/MCB.25.23.10338-10351.2005. PMC 1291230. PMID 16287849.
Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Beausoleil SA, Villén J, Gerber SA et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Reeves M, Murphy J, Greaves R et al. (2006). "Autorepression of the Human Cytomegalovirus Major Immediate-Early Promoter/Enhancer at Late Times of Infection Is Mediated by the Recruitment of Chromatin Remodeling Enzymes by IE86". J. Virol. 80 (20): 9998–10009. doi:10.1128/JVI.01297-06. PMC 1617317. PMID 17005678.
Estève PO, Chin HG, Smallwood A et al. (2006). "Direct interaction between DNMT1and G9a coordinates DNA and histone methylation during replication". Genes Dev. 20 (22): 3089–103. doi:10.1101/gad.1463706. PMC 1635145. PMID 17085482.

PDB gallery

2o8j: Human euchromatic histone methyltransferase 2

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EHMT2

Interactions

References

Further reading