EHD2

From Wikipedia, the free encyclopedia

EH-domain containing 2

Identifiers

EHD2; PAST2

External IDs

OMIM: 605890 MGI: 2154274 HomoloGene: 22825 GeneCards: EHD2 Gene

Gene Ontology
Molecular function	• nucleic acid binding • GTPase activity • calcium ion binding • protein binding • ATP binding • GTP binding • protein domain specific binding
Cellular component	• nucleus • plasma membrane • endosome membrane • perinuclear region of cytoplasm • recycling endosome membrane
Biological process	• endocytosis • blood coagulation • cortical actin cytoskeleton organization • endocytic recycling
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
48.22 – 48.25 Mb

Chr 7:
15.95 – 15.97 Mb

PubMed search

EH-domain containing 2, also known as EHD2, is a human gene^[1] belonging to the EHD protein family.

References

↑ "Entrez Gene: EHD2 EH-domain containing 2".

Pohl U, Smith JS, Tachibana I, et al. (2000). "EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins.". Genomics 63 (2): 255–62. doi:10.1006/geno.1999.6087. PMID 10673336.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Guilherme A, Soriano NA, Bose S, et al. (2004). "EHD2 and the novel EH domain binding protein EHBP1 couple endocytosis to the actin cytoskeleton.". J. Biol. Chem. 279 (11): 10593–605. doi:10.1074/jbc.M307702200. PMID 14676205.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Park SY, Ha BG, Choi GH, et al. (2004). "EHD2 interacts with the insulin-responsive glucose transporter (GLUT4) in rat adipocytes and may participate in insulin-induced GLUT4 recruitment.". Biochemistry 43 (23): 7552–62. doi:10.1021/bi049970f. PMID 15182197.
Aboulaich N, Vainonen JP, Strålfors P, Vener AV (2005). "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.". Biochem. J. 383 (Pt 2): 237–48. doi:10.1042/BJ20040647. PMC 1134064. PMID 15242332.
Guilherme A, Soriano NA, Furcinitti PS, Czech MP (2004). "Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes.". J. Biol. Chem. 279 (38): 40062–75. doi:10.1074/jbc.M401918200. PMID 15247266.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

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EHD2

References

Further reading