EGIS-12,233

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EGIS-12,233
Systematic (IUPAC) name
5,7-dichloro-3-[4-[4-(4-chlorophenyl)piperazin-1-yl]butyl]-3-ethyl-indolin-2-one
Clinical data
Legal status ?
Identifiers
ATC code None
PubChem CID 11525867
Chemical data
Formula C24H28Cl3N3O 
Mol. mass 480.856 g/mol
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EGIS-12,233 is a drug with applications in scientific research, acting as a potent and selective antagonist for both the 5-HT6 and 5-HT7 serotonin receptor subtypes, with good selectivity over other receptors.[1] It has been shown to increase dopamine release in cochlear tissue, suggesting a role for the 5-HT6 and 5-HT7 receptors in regulation of the hearing system.[2]

References

  1. ↑ Volk, B; Barkóczy, J; Hegedus, E; Udvari, S; Gacsályi, I; Mezei, T; Pallagi, K; Kompagne, H et al. (2008). "(Phenylpiperazinyl-butyl)oxindoles as selective 5-HT7 receptor antagonists". Journal of Medical Chemistry 51 (8): 2522–32. doi:10.1021/jm070279v. PMID 18361484. 
  2. ↑ Doleviczényi, Z; Vizi, ES; Gacsályi, I; Pallagi, K; Volk, B; Hársing Jr, LG; Halmos, G; Lendvai, B et al. (2008). "5-HT6/7 receptor antagonists facilitate dopamine release in the cochlea via a GABAergic disinhibitory mechanism". Neurochemical research 33 (11): 2364–72. doi:10.1007/s11064-008-9796-4. PMID 18663573. 


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