EED
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- Or see End-to-end distance.
| Embryonic ectoderm development | |||||||||||||
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 Rendering based on PDB 3IIW. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | EED; HEED; WAIT1 | ||||||||||||
| External IDs | OMIM: 605984 MGI: 95286 HomoloGene: 2814 GeneCards: EED Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8726 | 13626 | |||||||||||
| Ensembl | ENSG00000074266 | ENSMUSG00000030619 | |||||||||||
| UniProt | O75530 | Q921E6 | |||||||||||
| RefSeq (mRNA) | NM_003797 | NM_021876 | |||||||||||
| RefSeq (protein) | NP_003788 | NP_068676 | |||||||||||
| Location (UCSC) | Chr 11: 85.96 – 85.99 Mb | Chr 7: 89.95 – 89.98 Mb | |||||||||||
| PubMed search | |||||||||||||
Polycomb protein EED is a protein that in humans is encoded by the EED gene.[1][2][3]
Function
Polycomb protein EED is a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin β7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene.[3]
Interactions
EED has been shown to interact with HDAC1,[4] Histone deacetylase 2,[4] PPP1R8,[5] TGS1,[6] EZH2[4][7][8] and ITGB7.[1]
References
- ↑ 1.0 1.1 Rietzler M, Bittner M, Kolanus W, Schuster A, Holzmann B (Nov 1998). "The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins". J Biol Chem 273 (42): 27459–66. doi:10.1074/jbc.273.42.27459. PMID 9765275.
- ↑ Schumacher A, Lichtarge O, Schwartz S, Magnuson T (Jan 1999). "The murine Polycomb-group gene eed and its human orthologue: functional implications of evolutionary conservation". Genomics 54 (1): 79–88. doi:10.1006/geno.1998.5509. PMID 9806832.
- ↑ 3.0 3.1 "Entrez Gene: EED embryonic ectoderm development".
- ↑ 4.0 4.1 4.2 van der Vlag, J; Otte A P (Dec 1999). "Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation". Nat. Genet. (UNITED STATES) 23 (4): 474–8. doi:10.1038/70602. ISSN 1061-4036. PMID 10581039.
- ↑ Jin, Qiming; van Eynde Aleyde, Beullens Monique, Roy Nivedita, Thiel Gerald, Stalmans Willy, Bollen Mathieu (Aug 2003). "The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor". J. Biol. Chem. (United States) 278 (33): 30677–85. doi:10.1074/jbc.M302273200. ISSN 0021-9258. PMID 12788942.
- ↑ Enünlü, Izzet; Pápai Gábor, Cserpán Imre, Udvardy Andor, Jeang Kuan-Teh, Boros Imre (Sep 2003). "Different isoforms of PRIP-interacting protein with methyltransferase domain/trimethylguanosine synthase localizes to the cytoplasm and nucleus". Biochem. Biophys. Res. Commun. (United States) 309 (1): 44–51. doi:10.1016/S0006-291X(03)01514-6. ISSN 0006-291X. PMID 12943661.
- ↑ van Lohuizen, M; Tijms M, Voncken J W, Schumacher A, Magnuson T, Wientjens E (Jun 1998). "Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes". Mol. Cell. Biol. (UNITED STATES) 18 (6): 3572–9. ISSN 0270-7306. PMC 108938. PMID 9584197.
- ↑ Denisenko, O; Shnyreva M, Suzuki H, Bomsztyk K (Oct 1998). "Point mutations in the WD40 domain of Eed block its interaction with Ezh2". Mol. Cell. Biol. (UNITED STATES) 18 (10): 5634–42. ISSN 0270-7306. PMC 109149. PMID 9742080.
Further reading
- Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection.". Curr. HIV Res. 3 (1): 87–94. doi:10.2174/1570162052773013. PMID 15638726.
- Van Maele B, Debyser Z (2005). "HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins.". AIDS reviews 7 (1): 26–43. PMID 15875659.
- Jones CA, Ng J, Peterson AJ, et al. (1998). "The Drosophila esc and E(z) proteins are direct partners in polycomb group-mediated repression.". Mol. Cell. Biol. 18 (5): 2825–34. PMC 110661. PMID 9566901.
- van Lohuizen M, Tijms M, Voncken JW, et al. (1998). "Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes.". Mol. Cell. Biol. 18 (6): 3572–9. PMC 108938. PMID 9584197.
- Sewalt RG, van der Vlag J, Gunster MJ, et al. (1998). "Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes.". Mol. Cell. Biol. 18 (6): 3586–95. PMC 108940. PMID 9584199.
- Denisenko O, Shnyreva M, Suzuki H, Bomsztyk K (1998). "Point mutations in the WD40 domain of Eed block its interaction with Ezh2.". Mol. Cell. Biol. 18 (10): 5634–42. PMC 109149. PMID 9742080.
- Peytavi R, Hong SS, Gay B, et al. (1999). "HEED, the product of the human homolog of the murine eed gene, binds to the matrix protein of HIV-1.". J. Biol. Chem. 274 (3): 1635–45. doi:10.1074/jbc.274.3.1635. PMID 9880543.
- van der Vlag J, Otte AP (1999). "Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation.". Nat. Genet. 23 (4): 474–8. doi:10.1038/70602. PMID 10581039.
- Satijn DP, Hamer KM, den Blaauwen J, Otte AP (2001). "The polycomb group protein EED interacts with YY1, and both proteins induce neural tissue in Xenopus embryos.". Mol. Cell. Biol. 21 (4): 1360–9. doi:10.1128/MCB.21.4.1360-1369.2001. PMC 99588. PMID 11158321.
- Kuzmichev A, Nishioka K, Erdjument-Bromage H, et al. (2002). "Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.". Genes Dev. 16 (22): 2893–905. doi:10.1101/gad.1035902. PMC 187479. PMID 12435631.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Jin Q, van Eynde A, Beullens M, et al. (2003). "The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor.". J. Biol. Chem. 278 (33): 30677–85. doi:10.1074/jbc.M302273200. PMID 12788942.
- Enünlü I, Pápai G, Cserpán I, et al. (2003). "Different isoforms of PRIP-interacting protein with methyltransferase domain/trimethylguanosine synthase localizes to the cytoplasm and nucleus.". Biochem. Biophys. Res. Commun. 309 (1): 44–51. doi:10.1016/S0006-291X(03)01514-6. PMID 12943661.
- Violot S, Hong SS, Rakotobe D, et al. (2004). "The human polycomb group EED protein interacts with the integrase of human immunodeficiency virus type 1.". J. Virol. 77 (23): 12507–22. doi:10.1128/JVI.77.23.12507-12522.2003. PMC 262565. PMID 14610174.
- Witte V, Laffert B, Rosorius O, et al. (2004). "HIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group protein Eed to the plasma membrane.". Mol. Cell 13 (2): 179–90. doi:10.1016/S1097-2765(04)00004-8. PMID 14759364.
- Cao R, Zhang Y (2004). "SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex.". Mol. Cell 15 (1): 57–67. doi:10.1016/j.molcel.2004.06.020. PMID 15225548.
- Pasini D, Bracken AP, Jensen MR, et al. (2004). "Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity.". EMBO J. 23 (20): 4061–71. doi:10.1038/sj.emboj.7600402. PMC 524339. PMID 15385962.
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