E4F1
From Wikipedia, the free encyclopedia
Transcription factor E4F1 is a protein that in humans is encoded by the E4F1 gene.[1][2][3]
The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence.[3]
Interactions
E4F1 has been shown to interact with P16,[4] Retinoblastoma protein[5] and P53.[4][6]
References
- ↑ Saccone S, Sandy P, Meroni G, Gostissa M, Della Valle G, Del Sal G (November 1998). "Assignment of the E1A-regulated transcription factor E4F gene (E4F1) to human chromosome band 16p13.3 by in situ hybridization and somatic cell hybrids". Cytogenet Cell Genet 82 (1-2): 99–100. doi:10.1159/000015075. PMID 9763670.
- ↑ Burn TC, Connors TD, Van Raay TJ, Dackowski WR, Millholland JM, Klinger KW, Landes GM (December 1996). "Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3". Genome Res 6 (6): 525–37. doi:10.1101/gr.6.6.525. PMID 8828041.
- ↑ 3.0 3.1 "Entrez Gene: E4F1 E4F transcription factor 1".
- ↑ 4.0 4.1 Rizos, Helen; Diefenbach Eve, Badhwar Prerna, Woodruff Sarah, Becker Therese M, Rooney Robert J, Kefford Richard F (February 2003). "Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition". J. Biol. Chem. (United States) 278 (7): 4981–9. doi:10.1074/jbc.M210978200. ISSN 0021-9258. PMID 12446718.
- ↑ Fajas, L; Paul C, Zugasti O, Le Cam L, Polanowska J, Fabbrizio E, Medema R, Vignais M L, Sardet C (July 2000). "pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (14): 7738–43. doi:10.1073/pnas.130198397. ISSN 0027-8424. PMC 16614. PMID 10869426.
- ↑ Sandy, P; Gostissa M, Fogal V, Cecco L D, Szalay K, Rooney R J, Schneider C, Del Sal G (January 2000). "p53 is involved in the p120E4F-mediated growth arrest". Oncogene (ENGLAND) 19 (2): 188–99. doi:10.1038/sj.onc.1203250. ISSN 0950-9232. PMID 10644996.
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Fernandes ER, Rooney RJ (1997). "The adenovirus E1A-regulated transcription factor E4F is generated from the human homolog of nuclear factor phiAP3.". Mol. Cell. Biol. 17 (4): 1890–903. PMC 232036. PMID 9121437.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Rooney RJ, Daniels RR, Jenkins NA, et al. (1998). "Chromosomal location and tissue expression of the gene encoding the adenovirus E1A-regulated transcription factor E4F in humans and mice.". Mamm. Genome 9 (4): 320–3. doi:10.1007/s003359900758. PMID 9530632.
- Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members.". J. Biol. Chem. 274 (53): 37538–43. doi:10.1074/jbc.274.53.37538. PMID 10608806.
- Sandy P, Gostissa M, Fogal V, et al. (2000). "p53 is involved in the p120E4F-mediated growth arrest.". Oncogene 19 (2): 188–99. doi:10.1038/sj.onc.1203250. PMID 10644996.
- Fajas L, Paul C, Zugasti O, et al. (2000). "pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F.". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7738–43. doi:10.1073/pnas.130198397. PMC 16614. PMID 10869426.
- Rizos H, Diefenbach E, Badhwar P, et al. (2003). "Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition.". J. Biol. Chem. 278 (7): 4981–9. doi:10.1074/jbc.M210978200. PMID 12446718.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Fenton SL, Dallol A, Agathanggelou A, et al. (2004). "Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene.". Cancer Res. 64 (1): 102–7. doi:10.1158/0008-5472.CAN-03-2622. PMID 14729613.
- Nakamura Y, Igarashi K, Suzuki T, et al. (2005). "E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis.". Am. J. Pathol. 165 (6): 2019–31. PMC 1618705. PMID 15579445.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Paul C, Lacroix M, Iankova I, et al. (2006). "The LIM-only protein FHL2 is a negative regulator of E4F1.". Oncogene 25 (40): 5475–84. doi:10.1038/sj.onc.1209567. PMID 16652157.
- Le Cam L, Linares LK, Paul C, et al. (2006). "E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation.". Cell 127 (4): 775–88. doi:10.1016/j.cell.2006.09.031. PMID 17110336.
- Cvetanovic M, Rooney RJ, Garcia JJ, et al. (2007). "The role of LANP and ataxin 1 in E4F-mediated transcriptional repression.". EMBO Rep. 8 (7): 671–7. doi:10.1038/sj.embor.7400983. PMC 1905893. PMID 17557114.
External links
- E4F1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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