E-6801

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E-6801
IUPAC name

(6-chloro-N-(3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)imidazo[2,1-b]thiazole-5-sulfonamide)

Properties
Molecular formula C17H18ClN5O2S2
Molar mass 423.94 g mol-1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

E-6801 is a partial agonist of the 5-HT6 receptor.[1] It enhanced recognition memory and reversed the memory deficits of scopolamine in an object recognition task in a rat model.[2] The mechanism of memory enhancement is due to a combined modulation of cholinergic and glutamatergic neurotransmission.

See also

References

  1. ↑ Romero, G. (August 2006). "Efficacy of selective 5-HT6 receptor ligands determined by monitoring 5-HT6 receptor-mediated cAMP signaling pathways". British Journal of Pharmacology 148 (8): 1133–43. doi:10.1038/sj.bjp.0706827. PMC 1752021. PMID 16865095. Retrieved 24 December 2011. 
  2. ↑ Kendall, I. (February 2011). "E-6801, a 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat.". Psychopharmacology 213 (2-3): 413–30. doi:10.1007/s00213-010-1854-3. PMID 20405281. 


Antiobesity agents/Anorectics (A08)
Central
Drinabant§ • Ibipinabant§ • Otenabant§ • Rimonabant‡ • Rosonabant§ • Surinabant§ • Taranabant§
Others
5-HTP • Galactomannan (Guar gum) • Glucomannan • L-DOPA • L-Phenylalanine • L-Tryptophan • L-Tyrosine • Lorcaserin • Lu AA-33810 • Metformin • Naltrexone • Naloxone • Oxyntomodulin • P57 • Peptide YY • Topiramate • Yohimbine (Yohimbe) • Zonisamide
Peripheral

M: NUT

cof, enz, met

noco, nuvi, sysi/epon, met

drug (A8/11/12)

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