Drosophila C virus
| Drosophila C virus | |
|---|---|
| Virus classification | |
| Group: | Group IV ((+)ssRNA) |
| Order: | Picornavirales |
| Family: | Dicistroviridae |
| Genus: | Cripavirus |
| Species: | Drosophila C virus |
Drosophila C virus belongs to the genus Cripavirus and was previously thought to be a member of the virus family Picornaviridae; it has since been classified as belonging to the Dicistroviridae.[1] It is a single stranded positive sense RNA virus of approximately 9300 nucleotides and it contains two open reading frames.[1] The virus particles are 30 nm in diameter and are made up of approximately 30% of RNA and 70% protein.[2] The virus capsid is composed of three major polypeptides and two minor polypeptides.[2]
Drosophila C virus was first discovered in the early 1970s in a French strain of Drosophila melanogaster,[1] but can also infect other Drosophila species in laboratory settings.[3] The virus is transmitted by feeding and has small effects on survival and immune response.[4] However, experimental evidence has shown that when injected into adult flies the virus is pathogenic as it causes the adult flies to die within 3–4 days following injection and induces many genes involved in immune response.[1] Drosophila that are infected with Drosophila C virus develop more quickly, the females are heavier and produce more eggs therefore more offspring in comparison to drosophila not infected with the virus.[1] Infection with Drosophila C virus can also increase mortality rate within a drosophila population.[5]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Genomes
- ↑ 2.0 2.1 Characterization of the Drosophila C Virus - Jousset et al. 34 (2): 269 - Journal of General Virology
- ↑ Kapun, M; Nolte, V; Flatt, T; Schlötterer, C (2010). "Host range and specificity of the Drosophila C virus.". PloS one 5 (8): e12421. PMID 20865043.
- ↑ Roxström-Lindquist, K; Terenius, O; Faye, I (2004). "Parasite-specific immune response in adult Drosophila melanogaster: a genomic study.". EMBO reports 5 (2): 207–12. PMID 14749722.
- ↑ Gravot, E; Thomas-Orillard, M; Jeune, B (2000). "Virulence variability of the Drosophila C virus and effects of the microparasite on demographic parameters of the host (Drosophila melanogaster).". Journal of invertebrate pathology 75 (2): 144–51. PMID 10772327.