Diphenadione

Diphenadione
IUPAC name 2-(Diphenylacetyl)-1H-indene-1,3(2H)-dione
Other names Diphacinone; Diphenandione
Identifiers
CAS number	82-66-6 Y
PubChem	6719
ChemSpider	6463
UNII	54CA01C6JX Y
KEGG	D07136 Y
ChEMBL	CHEMBL1413199
ATC code	B01AA10
Jmol-3D images	Image 1
SMILES O=C2c1ccccc1C(=O)C2C(=O)C(c3ccccc3)c4ccccc4
InChI InChI=1S/C23H16O3/c24-21-17-13-7-8-14-18(17)22(25)20(21)23(26)19(15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14,19-20H Key: JYGLAHSAISAEAL-UHFFFAOYSA-N InChI=1/C23H16O3/c24-21-17-13-7-8-14-18(17)22(25)20(21)23(26)19(15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14,19-20H Key: JYGLAHSAISAEAL-UHFFFAOYAR
Properties
Molecular formula	C23H16O3
Molar mass	340.37 g mol−1
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Diphenadione is a vitamin K antagonist which has anticoagulant effects and is used as a rodenticide against rats, mice, voles, ground squirrels and other rodents. This chemical compound is an anti-coagulant with longer activity than warfarin and other synthetic indandione anticoagulants.^[1]

Safety and toxicity

Diphenadione is highly toxic for human skin by all means of contact. The consumption of drug may cause major blood clotting and irregular heartbeats.^[2] An online pesticide database gives more information about the safety of diphenadione.^[3] The U.S. Environmental Protection Agency has issued a safety handbook which explains how incidents of poisoning with similar rodenticides are usually treated.^[4] For treatment purposes Vitamin K antagonists like diphenadione are placed under the heading of coumarins and indandiones. The handbook notes that "...as agents specifically designed to kill mammals, often their toxicity is very similar for the target rodents and for humans."^[5]

References