Dipeptidase 1

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Dipeptidase 1 (renal)

PDB rendering based on 1itq.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsDPEP1; MBD1; MDP; RDP
External IDsOMIM: 179780 MGI: 94917 HomoloGene: 80192 ChEMBL: 1989 GeneCards: DPEP1 Gene
EC number3.4.13.19
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez180013479
EnsemblENSG00000015413ENSMUSG00000019278
UniProtP16444P31428
RefSeq (mRNA)NM_001128141NM_007876
RefSeq (protein)NP_001121613NP_031902
Location (UCSC)Chr 16:
89.68 – 89.7 Mb
Chr 8:
123.19 – 123.2 Mb
PubMed search

Dipeptidase 1 is an enzyme that in humans is encoded by the DPEP1 gene.[1]

DPEP1 (EC 3.4.13.11) is a kidney membrane enzyme that hydrolyzes a variety of dipeptides and is implicated in renal metabolism of glutathione and its conjugates, e.g., leukotriene D4 (Kozak and Tate, 1982). DPEP1 is responsible for hydrolysis of the beta-lactam ring of antibiotics, such as penem and carbapenem (Campbell et al., 1984). Earlier, beta-lactamase enzymes were thought to occur only in bacteria, where their probable function was in protecting the organisms against the action of beta-lactam antibiotics. These antibiotics exhibit selective toxicity against bacteria but virtual inertness against many eukaryotic cells (Adachi et al., 1990).[supplied by OMIM][1]

Interactions

Dipeptidase 1 has been shown to interact with KIAA1279.[2]

References

  1. 1.0 1.1 "Entrez Gene: DPEP1 dipeptidase 1 (renal)". 
  2. Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading


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