Dimenoxadol

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Dimenoxadol

Systematic (IUPAC) name
2-(dimethylamino)ethyl 2-ethoxy-2,2-diphenylacetate
Clinical data
Legal status	Prohibited (S9) (AU) Schedule I (US)
Identifiers
CAS number	509-78-4^Y
ATC code	None
PubChem	CID 17036
DrugBank	DB01461
ChemSpider	16137^Y
UNII	4D65PBX0VK^Y
Synonyms	Dimenoxadol, Estocin
Chemical data
Formula	C₂₀H₂₅N O₃
Mol. mass	327.42 g/mol
SMILES Cl.CCOC(C(=O)OCCN(C)C)(c1ccccc1)c1ccccc1
InChI InChI=1S/C20H25NO3/c1-4-24-20(17-11-7-5-8-12-17,18-13-9-6-10-14-18)19(22)23-16-15-21(2)3/h5-14H,4,15-16H2,1-3H3^Y Key:RHUWRJWFHUKVED-UHFFFAOYSA-N^Y
Y (what is this?) (verify)

Dimenoxadol (INN; Estocin), or dimenoxadole (BAN), is an opioid analgesic which is a benzilic acid derivative, closely related to benactyzine (an anticholinergic). Further, the structure is similar to methadone and related compounds like dextropropoxyphene.

It was invented in Germany in the 1950s,^[1] and produces similar effects to other opioids, including analgesia, sedation, dizziness and nausea.^[2]^[3]^[4]

References

↑ GB 716700, Boehringer, A et al., "A new and improved analgesic and process for its production", published 10/13/1954
↑ Gorbatova, E. N. (1967). "The pharmacology of estocin, an new analgesic". Stomatologiia 46 (2): 22–25. PMID 5232927.
↑ Kingisepp, G. A.; Kurvits, K.; Nurmand, L. B. (1969). "Pharmacology of dimethylaminoethyl ester of diphenylethoxyacetic acid hydrochloride--estocin". Farmakologiia i toksikologiia 32 (6): 710–712. PMID 5381602.
↑ Liberman, S. S. (1968). "Analgesic action of estocin (dimethylaminoethyl ester hydrochloride of alpha, alpha-diphenylethoxyacetic acid)". Farmakologiia i toksikologiia 31 (6): 668–671. PMID 5729519.

Analgesics (N02A, N02B)

Opioids
See also: Opioids template

Opium & alkaloids thereof	Codeine^# Morphine^# Opium Laudanum Paregoric

Semi-synthetic opium derivatives	Acetyldihydrocodeine Benzylmorphine Buprenorphine Desomorphine Diacetylmorphine Dihydrocodeine Dihydromorphine Ethylmorphine Hydrocodone Hydromorphinol Hydromorphone Nicocodeine Nicodicodeine Nicomorphine Oxycodone Oxymorphone

Synthetic opioids	Alphaprodine Anileridine Butorphanol Dextromoramide Dextropropoxyphene Dezocine Fentanyl Ketobemidone Levorphanol Meptazinol Methadone Nalbuphine Pentazocine Pethidine Phenazocine Piminodine Piritramide Propiram Tapentadol Tilidine Tramadol

Pyrazolones

Cannabinoids

Anilides

Non-steroidal
anti-inflammatories
See also: NSAIDs template

Propionic acid class	Fenoprofen Flurbiprofen Ibuprofen^# Ketoprofen Naproxen Oxaprozin

Oxicam class	Meloxicam Piroxicam

Acetic acid class	Diclofenac Indometacin Ketorolac Nabumetone Sulindac Tolmetin

COX-2 inhibitors	Celecoxib Lumiracoxib Parecoxib Rofecoxib Valdecoxib

Anthranilic acid (fenamate) class	Meclofenamic acid Mefenamic acid

Salicylates	Aspirin (Acetylsalicylic acid)^# (+paracetamol/caffeine) Benorylate Diflunisal Ethenzamide Magnesium salicylate Salicin Salicylamide Salsalate Trisalate Wintergreen (Methyl salicylate)

Atypical, adjuvant and potentiators,
metabolic agents and miscellaneous

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

M: CNS

anat (n/s/m/p/4/e/b/d/c/a/f/l/g)/phys/devp

noco (m/d/e/h/v/s)/cong/tumr, sysi/epon, injr

proc, drug (N1A/2AB/C/3/4/7A/B/C/D)

Opioids

Opium and
poppy straw
derivatives

Crude opiate
extracts /
whole opium
products

Natural opiates

Opium alkaloids	Codeine Morphine Oripavine Pseudomorphine Thebaine

Alkaloid salts mixtures	Pantopon Papaveretum (Omnopon)

Semisynthetics
including
Bentley
compounds

Morphine family	2,4-Dinitrophenylmorphine 6-MDDM Azidomorphine Chlornaltrexamine Desocodeine Desomorphine Dihydromorphine Hydromorphinol Methyldesorphine N-Phenethylnormorphine RAM-378

3,6-diesters of morphine	Acetylpropionylmorphine Diacetyldihydromorphine Dibenzoylmorphine Dipropanoylmorphine Heroin Nicomorphine

Codeine-dionine family	6-Monoacetylcodeine Benzylmorphine Codeine methylbromide Ethylmorphine Heterocodeine Isocodeine Myrophine Pholcodine

Morphinones and morphols	14-Cinnamoyloxycodeinone 14-Ethoxymetopon 14-Methoxymetopon 14-Phenylpropoxymetopon 3-Acetyloxymorphone 3,14-Diacetyloxymorphone 6-MDDM 7-Spiroindanyloxymorphone Acetylmorphone Codeinone Codoxime Conorfone Hydrocodone Hydromorphone IBNtxA Methyldihydromorphine Metopon Morphinone N-Phenethyl-14-ethoxymetopon Nalmexone Oxycodone Oxymorphol Oxymorphone Pentamorphone Semorphone Thebacon

Morphides	α-Chlorocodide Chloromorphide

Dihydrocodeine series	14-Hydroxydihydrocodeine Acetyldihydrocodeine Dihydrocodeine Nicocodeine Nicodicodeine

Nitrogen morphine derivatives	Codeine-N-oxide Morphine-N-oxide

Hydrazones	Oxymorphazone

Halogenated morphine derivatives	1-Iodomorphine

Active opiate
metabolites

Morphinans

Benzomorphans

4-Phenylpiperidines

Pethidines (Meperidines)	4-Fluoropethidine Allylnorpethidine Anileridine Benzethidine Carperidine Difenoxin Diphenoxylate Etoxeridine (Carbetidine) Furethidine Hydroxypethidine (Bemidone) Morpheridine Oxpheneridine (Carbamethidine) Pethidine (Meperidine) Pethidine intermediate A Pethidine intermediate B (Norpethidine) Pethidine intermediate C (Pethidinic Acid) Pheneridine Phenoperidine Piminodine Properidine (Ipropethidine) Sameridine

Prodines	Allylprodine Meprodine (α-meprodine / β-meprodine) MPPP (Desmethylprodine) PEPAP Prodine (α-prodine / β-prodine) Prosidol Trimeperidine (Promedol)

Ketobemidones	Acetoxyketobemidone Droxypropine Ketobemidone Methylketobemidone Propylketobemidone

Others	Alvimopan Loperamide Picenadol

Open chain
opioids

Amidones	Dipipanone Isomethadone Levomethadone Methadone Normethadone Norpipanone Phenadoxone (Heptazone)

Methadols	Acetylmethadol Alphacetylmethadol Alphamethadol Betacetylmethadol Betamethadol Dimepheptanol (methadol) Isomethadol Levacetylmethadol Noracymethadol

Moramides	Desmethylmoramide Dextromoramide Levomoramide Moramide/Racemoramide

Thiambutenes	Diethylthiambutene Dimethylthiambutene Ethylmethylthiambutene Piperidylthiambutene Pyrrolidinylthiambutene Tipepidine

Phenalkoxams	Dextropropoxyphene Dimenoxadol Dioxaphetyl butyrate Levopropoxyphene Norpropoxyphene

Ampromides	Diampromide Phenampromide Propiram

Others	Alimadol IC-26 Isoaminile Lefetamine R-4066

Anilidopiperidines

Oripavine
derivatives

Phenazepanes

Pirinitramides

Benzimidazoles

Indoles

Diphenylmethyl-
piperazines

Opioid peptides

Others

Opioid
antagonists &
inverse agonists

Biased ligands

Uncategorized
opioids

List of opioids

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