Dihydropyridine

From Wikipedia, the free encyclopedia

Dihydropyridine

Systematic name 1,4-Dihydropyridine^[1]
Identifiers
CAS number	3337-17-5^Y
PubChem	104822
ChemSpider	94619^Y
MeSH	1,4-dihydropyridine
Jmol-3D images	Image 1
SMILES C1C=CNC=C1
InChI InChI=1S/C5H7N/c1-2-4-6-5-3-1/h2-6H,1H2^Y Key: YNGDWRXWKFWCJY-UHFFFAOYSA-N^Y
Properties
Molecular formula	C 5H 7N
Molar mass	81.1158 g mol^-1
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Dihydropyridine is a molecule based upon pyridine, and the parent of a class of molecules that have been semi-saturated with two substituents replacing one double bond. They are particularly well known in pharmacology as L-type calcium channel blockers, used in the treatment of hypertension. Compared with certain other L-type calcium channel blockers (for example those of the phenylalkylamine class such as Verapamil) which have significant action at the heart, they are relatively vascular selective in their mechanism of action in lowering blood pressure.

Class members

The L-type calcium channel blockers include, in alphabetical order (brand names vary in different countries):

Name	Image	Brand name	Discovered
Amlodipine		Norvasc, Istin
Aranidipine
Azelnidipine
Barnidipine
Benidipine
Cilnidipine
Clevidipine
Cronidipine
Darodipine
Dexniguldipine
Efonidipine
Elnadipine
Elgodipine
Felodipine		Renedil, Plendil
Flordipine
Furnidipine
Iganidipine
Isradipine
Lacidipine
Lemildipine
Lercanidipine		Zanidip
Manidipine
Mesuldipine
Nicardipine		Cardene
Nifedipine		Adalat, Nifedical, Procardia
Niguldipine
Nimodipine		Nimotop
Niludipine
Nilvadipine
Nisoldipine		Sular
Nitrendipine
Olradipine
Oxodipine
Palonidipine
Pranidipine
Sagandipine
Sornidipine
Teludipine
Tiamdipine
Trombodipine
Watanidipine

References

↑ "1,4-dihydropyridine - Compound Summary". Pubchem Compound. USA: National Center for Biotechnology Information. 27 March 2005. Identification and Related Records. Retrieved 1 November 2011.

External links

Dihydropyridines at the US National Library of Medicine Medical Subject Headings (MeSH)

v t e Channel blockers

Calcium (Ca²⁺)	Amlodipine Amrinone Anandamide Anipamil Aranidipine Azelnidipine Azimilide Barnidipine Bencyclane Benidipine Bepridil Berbamine Bevantolol Canadine Carboxyamidotriazole Caroverine Cilnidipine Cinnarizine Clentiazem Clevidipine Conotoxins Darodipine Dauricine Devapamil Diltiazem Dimeditiapramine Dotarizine Dronedarone Efonidipine Emopamil Enpiperate Eperisone Ethosuximide Falipamil Fantofarone Fasudil Felodipine Fenamic acid Fendiline Flunarizine Fostedil Gallopamil Isradipine Lacidipine Lamotrigine Lercanidipine Lidoflazine Magnesium sulfate Manidipine Manoalide Mepirodipine Mesuximide Mibefradil Monatepil Naftopidil Nicardipine Nifedipine Niguldipine Niludipin Nilvadipine Nimodipine Nisoldipine Nitrendipine Norverapamil Ochratoxin A Osthol Otilonium bromide Oxodipine Perhexiline Phensuximide Pinaverium Piperidine Pranidipine Prenylamine Risedronic acid Ryodipine Sesamodil Sodium valproate Stepholidine TROX-1 Terodiline Tetrahydropalmatine Tetrandrine Tolfenamic acid Tranilast Valnoctamide Valperinol Valproate pivoxil Valproate semisodium Valproic acid Valpromide Verapamil Ziconotide Selective VDCC ligands: 4-Methylpregabalin Atagabalin Gabapentin Gabapentin enacarbil Imagabalin PD-200,347 PD-217,014 PD-299,685 Pregabalin

Potassium (K⁺)	3,4-Diaminopyridine 4-Aminopyridine Amiodarone Bretylium Bunaftine Charybdotoxin Conotoxins Dofetilide Dronedarone E-4031 Ibutilide Linopirdine Maurotoxin Nifekalant Paxilline Sotalol Tedisamil Tetraethylammonium Vernakalant

Sodium (Na⁺)	Antiarrhythmics: Ajmaline Aprindine Disopyramide Dronedarone Encainide Flecainide Lidocaine Lorajmine Lorcainide Mexiletine Moricizine Phenytoin Pilsicainide Prajmaline Procainamide Propafenone Quinidine Sparteine Tocainide Anticonvulsants: Carbamazepine Eslicarbazepine acetate Ethotoin Fosphenytoin Licarbazepine Mephenytoin Oxcarbazepine Oxitriptyline Phenytoin Rufinamide Topiramate Sodium valproate Valnoctamide Valproate pivoxil Valproate semisodium Valproic acid Valpromide Diuretics: Amiloride Benzamil Triamterene Local anesthetics: pFBT Amylocaine Articaine Benzocaine Bupivacaine (Levobupivacaine, Ropivacaine) Butacaine Butamben Chloroprocaine Cinchocaine Cocaine Cyclomethycaine Dimethocaine Etidocaine Hexylcaine Iontocaine Lidocaine Mepivacaine Meprylcaine Metabutoxycaine Orthocaine Piperocaine Prilocaine Procaine Propoxycaine Proxymetacaine Risocaine Tetracaine Trimecaine Toxins: Conotoxins Neosaxitoxin Saxitoxin Tetrodotoxin Others: Menthol

Other	Uncategorized: Ethadione Paramethadione Phenacemide Pheneturide Trimethadione

This article is issued from Wikipedia. The text is available under the Creative Commons Attribution/Share Alike; additional terms may apply for the media files.

Dihydropyridine

Class members

See also

References

External links