Diclofenamide

Diclofenamide

Systematic (IUPAC) name
4,5-dichlorobenzene-1,3-disulfonamide
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a601233
Legal status	?
Pharmacokinetic data
Protein binding	55%
Identifiers
CAS number	120-97-8 Y
ATC code	S01EC02
PubChem	CID 3038
DrugBank	DB01144
ChemSpider	2930 Y
UNII	VVJ6673MHY Y
KEGG	D00518 Y
ChEBI	CHEBI:101085 Y
ChEMBL	CHEMBL17 Y
Chemical data
Formula	C6H6Cl2N2O4S2
Mol. mass	305.16 g/mol
SMILES Clc1c(cc(cc1Cl)S(=O)(=O)N)S(=O)(=O)N
InChI InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14) Y Key:GJQPMPFPNINLKP-UHFFFAOYSA-N Y
N (what is this?)  (verify)

Diclofenamide (or dichlorphenamide) is a sulfonamide and a carbonic anhydrase inhibitor of the meta-disulfamoylbenzene class.

Uses

Diclofenamide is used to treat glaucoma^[1][2] and therapy-resistant epilepsy.^[3]

References

• Tawil R, McDermott M, Brown R, Shapiro B, Ptacek L, McManis P, Dalakas M, Spector S, Mendell J, Hahn A, Griggs R (2000). "Randomized trials of dichlorphenamide in the periodic paralyses. Working Group on Periodic Paralysis.". Ann Neurol 47 (1): 46–53. doi:10.1002/1531-8249(200001)47:1<46::AID-ANA9>3.0.CO;2-H. PMID 10632100. 
• Okada S, Izumi W, Murai M, Komatsu H, Ishimitsu S (1991). "[Diclofenamide Reference Standard (Control 891) of National Institute of Hygienic Sciences]". Eisei Shikenjo Hokoku 109 (109): 148–50. PMID 1364383.