Deoxyribonuclease II

From Wikipedia, the free encyclopedia
deoxyribonuclease II alpha
Identifiers
Symbol DNASE2
Alt. symbols DNASE2A, DRN2, DNL, DNL2
Entrez 1777
HUGO 2960
OMIM 126350
RefSeq NM_001375
UniProt O00115
Other data
Locus Chr. 19 p13.2
deoxyribonuclease II beta
Identifiers
Symbol DNASE2B
Entrez 58511
HUGO 28875
OMIM 608057
RefSeq NM_021233
UniProt Q8WZ79
Other data
Locus Chr. 1 p22.3

Deoxyribonuclease II (EC 3.1.22.1, DNase II, pancreatic DNase II, deoxyribonucleate 3'-nucleotidohydrolase, pancreatic DNase II, acid deoxyribonuclease, acid DNase) hydrolyzes deoxyribonucleotide linkages in native and denatured DNA, yielding products with 3'-phosphates. As the name implies, it is more effective at acid pH.

There are several known DNases II, including:

  • DNase II alpha (usually just called DNase II)
  • DNase II beta (also called DLAD, or DNase II-Like Acid DNase)

External links

3.1.1: Carboxylic ester hydrolases
3.1.2: Thioesterase
3.1.3: Phosphatase
3.1.4: Phosphodiesterase
3.1.6: Sulfatase
Nuclease (includes
deoxyribonuclease and
ribonuclease)
3.1.11-16: Exonuclease
Exodeoxyribonuclease
Exoribonuclease
3.1.21-31: Endonuclease
Endodeoxyribonuclease
Endoribonuclease
either deoxy- or ribo-
  • B
  • enzm
  • 1.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
    • 10
    • 11
    • 13
    • 14
    • 15-18
  • 2.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
      • 2.7.10
      • 11-12
    • 8
  • 3.1
      • 3.1.3.48
    • 2
    • 3
    • 4
      • 3.4.21
      • 22
      • 23
      • 24
    • 5
    • 6
    • 7
  • 4.1
    • 2
    • 3
    • 4
    • 5
    • 6
  • 5.1
    • 2
    • 3
    • 4
    • 99
  • 6.1-3
    • 4
    • 5-6


This article is issued from Wikipedia. The text is available under the Creative Commons Attribution/Share Alike; additional terms may apply for the media files.