Dendrosome

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Dendrosomes [1] are novel vesicular, spherical, supramolecular entities wherein the dendrimer–nucleic acid complex is encapsulated within a lipophilic shell. They possess negligible hemolytic toxicity and higher transfection efficiency, and they are better tolerated in vivo than are dendrimers. The word " Dendrosome" came from the Greek word "Dendron" meaning tree and " some" means vesicles. Thus dendrosomes are vesicular structures composed of dendrimers.[2]

Applications

Dendrosomes have been explored as vectors in gene delivery [3] and genetic immunization.

Poly (propyleneimine) dendrosome based genetic immunization against Hepatitis B was found to be highly effective as compared to Dendrimer-Plasmid DNA complex. It has been postulated that in dendrosomes, the poly (propyleneimine) dendrimer–DNA complex is largely protected by multilamelarity of the vesicles. Moreover, it has been hypothesized that the lipoidal layers of the dendrosomes modifies the release pattern of the poly (propyleneimine) dendrimer –DNA complex, while some of the larger vesicles remain at the site of injection following their degradation by tissue phospholipases, the smaller ones delivering and transfecting efficiently the antigen-presenting cells (APC) in the draining lymph nodes.[4] Dendrosomes have also been explored for the delivery of s10siRNA targeting E6/E7 oncogenes in cervical cancer. It has been reported that polyamidoamine dendrimer based dendrosomes are efficient systems for the delivery of siRNA for effective management of cervical cancer.[5]

Toxicology

Dendrosome are reported to be completely nontoxic both in vitro as well as in vivo.[6] [7]

References

  1. ↑ M N Sarbolouki, M Sadeghizadeh, M M Yaghoobi, A Karami, T Lohrasbi. Dendrosomes: a novel family of vehicles for transfection and therapy. J. Chem. Tech. Biotechnol. 75: 919–922.
  2. ↑ Tathagata Dutta, Hrushikesh. B. Agashe, Vijayarajkumar, Mahendra Joshi, N. K. Jain Dendrosome Based Gene Delivery. J. of Exp. Nanoscience. 2006, 1(2): 235-248.
  3. ↑ Movassaghian S, Moghimi HR, Shirazi FH, Koshkaryev A, Trivedi MS, Torchilin VP, Efficient down-regulation of PKC-α gene expression in A549 lung cancer cells mediated by antisense oligodeoxynucleotides in dendrosomes. Int J Pharm. 2013 Jan 30;441(1-2):82-91
  4. ↑ Tathagata Dutta, Minakshi Garg, and N.K.Jain. Poly(propyleneimine) dendrimer and dendrosome based genetic immunization against Hepatitis B. Vaccine. 2008. 26(27-28): 3389-3394.
  5. ↑ Tathagata Dutta, Melinda Burgess, Nigel AJ McMillan, Harendra Parekh. Dendrosome based delivery of siRNA against E6/E7 Oncogenes in cervical cancer. Nanomedicine: Nanotechnology, Biology, and Medicine. 2010. doi:10.1016/j.nano.2009.12.001
  6. ↑ Tathagata Dutta, Melinda Burgess, Nigel AJ McMillan, Harendra Parekh. Dendrosome based delivery of siRNA against E6/E7 Oncogenes in cervical cancer. Nanomedicine: Nanotechnology, Biology, and Medicine. 2010. doi:10.1016/j.nano.2009.12.001
  7. ↑ Movassaghian S, Moghimi HR, Shirazi FH, Torchilin VP. Dendrosome-dendriplex inside liposomes: as a gene delivery system. J Drug Target. 2011 Dec;19(10):925-32. {{doi: 10.3109/1061186X.2011.628396}} Epub 2011 Oct 24.

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